Phenolic constituents, antimicrobial, antioxidant, and anticancer activities of ethyl acetate and n-butanol extracts of senna italica

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Khalaf O.M.; Ghareeb M.A.; Saad A.M.; Madkour H.M.F.; El-Ziaty A.K.; Abdel-Aziz M.S.

Journal: Acta Chromatographica

Publisher: Akademiai Kiado ZRt.

Publication Date: June 2019

Volume / Issue: Volume 31 / Issue 2

Pages: 138–145

ISSN: 20835736

DOI: 10.1556/1326.2018.00412

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Khalaf O.M., Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, Abbassia, Cairo, 11566, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba (P.O. 30), Giza, Egypt; Saad A.M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba (P.O. 30), Giza, Egypt; Madkour H.M.F., Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, Abbassia, Cairo, 11566, Egypt; El-Ziaty A.K., Chemistry Department, Faculty of Science, Ain Shams University, El-Khalifa El-Mamoun, Abbassia, Cairo, 11566, Egypt; Abdel-Aziz M.S., Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, El Behoos Street 33, Dokki-Giza, 12622, Egypt

Abstract

Different solvent extracts of the aerial parts of Senna italica (Mill.) were investigated for their chemical constituents and biological activities. Moreover, bio-guided fractionation led to isolation and identification of six compounds, namely: physcion (1), emodin (2), 2-methoxy-emodin-6-O-D-glucopyranoside (3), 1-hydroxy-2-acetyl-3-methyl-6-hydroxy-8-methoxynaphthalene (tinnevellin) (4), quercetin 3-O-L-rhamnopyranosyl-(16)-D-glucopyranoside (rutin) (5), and 1,6,8-trihydroxy-3-methoxy-9,10-dioxo-9,10-dihydroanthracene (6). The chemical structures of these compounds were established via 1D and 2D 1H-and 13C-NMR spectroscopy. Ethyl acetate and n-butanol extracts as well as compound 3 were evaluated for their anticancer activity against tumor cell lines. The tested extracts showed a moderate to weak activity, while compound 3 showed a moderate activity against human liver cancer (Hep G2) and breast cancer (MCF-7) cell lines with IC50 values of 57.5 and 42.3 g/mL, respectively. Both ethyl acetate and n-butanol extracts exhibited antimicrobial activities with different strengths, i.e., ethyl acetate exhibited antimicrobial activity against seven test microbes while n-butanol extract showed antimicrobial activity against all tested microbes. This is the first report for the isolation of compound 3 as a new compound from S. italica growing in Egypt. © 2019 Akademiai Kiado Rt.. All rights reserved.

Keywords

ABTS; Anthraquinones; Anticancer; Antimicrobial; Senna italica

Citation Information

Scopus Citations: 25

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