Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Younossi Z.; Tacke F.; Arrese M.; Chander Sharma B.; Mostafa I.; Bugianesi E.; Wai-Sun Wong V.; Yilmaz Y.; George J.; Fan J.; Vos M.B.

Journal: Hepatology

Publisher: John Wiley and Sons Inc.

Publication Date: 29 May 2019

Volume / Issue: Volume 69 / Issue 6

Pages: 2672–2682

ISSN: 2709139

DOI: 10.1002/hep.30251

Scopus: View on Scopus

PubMed: 30179269

Document Type: Review

Access: All Open Access; Green Open Access

Authors and Affiliations

Younossi Z., Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United States, Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Tacke F., Department of Medicine III, University Hospital Aachen, Aachen, Germany; Arrese M., Departamento de Gastroenterolog´ıa, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia, Chile; Chander Sharma B., Department of Gastroenterology, GIPMER, New Delhi, India; Mostafa I., Theodor Bilharz Research Institute, Cairo, Egypt; Bugianesi E., Division of Gastroenterology, University of Torino, Torino, Italy; Wai-Sun Wong V., Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong; Yilmaz Y., Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey; George J., Department of Gastroenterology & Hepatology, Westmead Hospital, University of Sydney, Australia; Fan J., Center for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Vos M.B., Department of Pediatrics, School of Medicine and Nutrition Health Sciences, Emory University, Atlanta, GA, United States, Children’s Healthcare of Atlanta, Atlanta, GA, United States

Abstract

Over the past 2 decades, nonalcoholic fatty liver disease (NAFLD) has grown from a relatively unknown disease to the most common cause of chronic liver disease in the world. In fact, 25% of the world’s population is currently thought to have NAFLD. Nonalcoholic steatohepatitis (NASH) is the subtype of NAFLD that can progress to cirrhosis, hepatocellular carcinoma (HCC), and death. NAFLD and NASH are not only found in adults—there is also a high prevalence of these diseases in children and adolescents. Because of the close association of NAFLD with type 2 diabetes (T2DM) and obesity, the latest models predict that the prevalence of NAFLD and NASH will increase, causing a tremendous clinical and economic burden and poor patient-reported outcomes. Nonetheless, there is no accurate noninvasive method to detect NASH, and treatment of this disease is limited to lifestyle modifications. To examine the state of NAFLD among different regions and understand the global trajectory of this disease, an international group of experts came together during the 2017 American Association for the Study of Liver Diseases Global NAFLD Forum. We provide a summary of this forum and an assessment of the current state of NAFLD and NASH worldwide. © 2018 by the American Association for the Study of Liver Diseases.

Keywords

Global Health; Humans; Incidence; Non-alcoholic Fatty Liver Disease; Prevalence; Africa; Asia; Australia; cardiovascular disease; clinical outcome; diabetes mellitus; economic evaluation; Europe; human; liver cell carcinoma; liver transplantation; metabolic syndrome X; Middle East; mortality; nonalcoholic fatty liver; nonalcoholic steatohepatitis; patient-reported outcome; priority journal; Review; Turkey (republic); Western Hemisphere; complication

Citation Information

Scopus Citations: 1680

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