Biological activities of endozoic fungi isolated from Biomphalaria alexandrina snails maintained in different environmental conditions

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Wareth M.T.A.; El-Hagrassi A.M.; Abdel-Aziz M.S.; Nasr S.M.; Ghareeb M.A.

Journal: International Journal of Environmental Studies

Publisher: Routledge

Publication Date: 30 May 2019

Volume / Issue: Volume 76 / Issue 5

Pages: 780–799

ISSN: 207233

DOI: 10.1080/00207233.2019.1620535

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Abdel-Wareth M.T.A., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; El-Hagrassi A.M., Phytochemistry and Plant Systematic Department, Pharmaceutical Industries Division, National Research Centre, Giza, Egypt; Abdel-Aziz M.S., Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt; Nasr S.M., Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt; Ghareeb M.A., Medicinal Chemistry, Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

This work aims at studying Biomphalaria alexandrina snails as a source of bioactive compounds. Adult snails were maintained in plastic, mud and cement matrices. Three groups were prepared; under normal laboratory conditions, in slightly low pH conditions, and in high temperature (30°C) conditions. Nine fungal species were isolated from soft tissues of snails. Ethyl acetate and acetone extracts were prepared from each fungal species, and their biological activities were investigated. Paecilomyces variotii extracts were the most effective as antimicrobial agents, while acetone extract of Trichoderma harzianum showed high antioxidant activity. Acetone extracts of Penicillium islandicum and Aspergillus niger were highly active against hepatocellular carcinoma (HepG2) cell lines. Gas chromatography/mass spectrometry analysis of the five effective extracts showed the presence of various compounds. B. alexandrina snails may be regarded as a newly discovered source of beneficial compounds through the metabolites produced by their endozoic fungal strains. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

anticancer; antimicrobial; antioxidant; Biomphalaria alexandrina; fungi; Acetone; Antimicrobial agents; Aspergillus; Bioactivity; Cell culture; Gas chromatography; Metabolites; Microorganisms; Molluscs; Acetone extracts; Bioactive compounds; Biomphalaria alexandrinum; Cement matrix; Environmental conditions; Fungal species; Mud matrix; Plastic matrices; Antioxidants

Citation Information

Scopus Citations: 23

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