Chromatographic isolation and structural elucidation of secondary metabolites from the soil-inhabiting fungus aspergillus fumigatus 3T-EGY

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Aziz M.S.; Ghareeb M.A.; Saad A.M.; Refahy L.A.; Hamed A.A.

Journal: Acta Chromatographica

Publisher: Akademiai Kiado ZRt.

Publication Date: December 2018

Volume / Issue: Volume 30 / Issue 4

Pages: 243–249

ISSN: 20835736

DOI: 10.1556/1326.2017.00329

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Abdel-Aziz M.S., Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, El-Bohouth Street 33, Dokki-Giza, 12622, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Saad A.M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Refahy L.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Hamed A.A., Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, El-Bohouth Street 33, Dokki-Giza, 12622, Egypt

Abstract

Eight compounds were isolated and identified from the soil-inhabiting fungus Aspergillus fumigatus 3T-EGY, namely, stearic acid (1), α-linolenic acid (2), physcion (3), di-(2-ethylhexyl) phthalate (4), 2,4,5,17-tetramethoxy pradimicin lactone (5), 3,5-dihydroxy-7-O-α-rhamnopyranoyl-2H-chromen-2-one (6), juglanthraquinone A-5-O-D-rhodosamine-(4′→1″)-2-deoxy-D-glucose (4″→1″′)-cinerulose B (7), and micropeptin (8). Their structures were determined on the basis of one-dimensional (1D-) and two-dimensional nuclear magnetic resonance (2D-NMR) [1H-,13C-NMR, 1H-1H COSY (COrrelated SpectroscopY), and 1H-13C HMBC (Heteronuclear Multiple Bond Correlation) spectroscopy]. Compound 7 showed moderate in vitro antimicrobial activity against three pathogenic strains with inhibition zones values were ranged from 9.0 to 10.66 mm compared to neomycin as a positive control with inhibition zones values were ranged from 14.0 to 19.0 mm. © 2017 The Author(s).

Keywords

Aspergillus fumigatus 3T-EGY; In vitro antimicrobial activity; Juglanthraquinone A triglycoside; Phenolics; VLC

Citation Information

Scopus Citations: 49

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