Evaluation of Fecal M2PK as a Diagnostic Marker in Colorectal Cancer

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Dabbous H.K.; Mohamed Y.A.E.-R.; El-Folly R.F.; El-Talkawy M.D.; Seddik H.E.; Johar D.; Sarhan M.A.

Journal: Journal of Gastrointestinal Cancer

Publisher: Humana Press Inc.

Publication Date: 7 April 2018

Volume / Issue: Volume 50 / Issue 3

Pages: 442–450

ISSN: 19416628

DOI: 10.1007/s12029-018-0088-1

Scopus: View on Scopus

PubMed: 29626277

Document Type: Article

Authors and Affiliations

Dabbous H.K., Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Mohamed Y.A.E.-R., Hepatogastroenterology and Tropical Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt; El-Folly R.F., Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; El-Talkawy M.D., Hepatogastroenterology and Tropical Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt; Seddik H.E., Hepatogastroenterology and Tropical Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt; Johar D., Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Cairo, Egypt, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 432 Basic Medical Sciences Building, 745 Bannatyne Avenue, Winnipeg, R3E 0J9, MB, Canada; Sarhan M.A., Center of Excellence of Gastrointestinal Inflammation and Immunology Research (CEGIIR), Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada, National Liver Institute, Department of Medical Microbiology and Immunology, Menofia University, Shibin El-Kom, Menofia, Egypt

Abstract

Background: Invasive colonoscopy is the gold standard for patients at risk for colorectal cancer. However, the need for non-invasive and specific markers is required. Objective: To evaluate the sensitivity of the glycolytic pyruvate kinase isoenzyme type M2 dimer (M2PK) as a diagnostic biomarker for colorectal cancer (CRC) and adenomatous colorectal polyps (CRP) screening. Design: Case-control. Patients: Twenty patients with CRC, 20 patients with CRP (lack criteria for colonic cancer by biopsy), and 20 normal subjects. Outcome: Complete blood count (CBC), erythrocyte sedimentation rate (ESR), tumor markers: carcino embryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), fecal occult blood test (FOBT), and fecal M2PK. Pelvic and abdominal ultrasound (US), colonoscopy, and a histopathological examination. Results: Only weight loss and cachexia were significantly associated with CRC than CRP or control groups. M2PK was the most sensitive and specific test in differentiating CRC from CRP and the control subjects (sensitivity = 75%, specificity = 100%). Limitations: (1) The selection of cases for three well-matched groups, as to perform colonoscopy in well-prepared cases and conditions. (2) Replicates in more than 20 cases for confirmation at the expense of enrolling new patients. (3) The cost associated with tumor markers analysis. Conclusion: Fecal M2PK can be used as a precolonoscopy screening test for CRC patients, and is superior to other tumor markers, and in indicating the progress of colorectal adenomas > 1 cm. Thus being cost-effective and easy-to-perform test, it is a feasible tool to preselect patients who require colonoscopy. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Colorectal cancer; Colorectal polyp; Egypt; Fecal occult blood test; Marker; Patients; Adenomatous Polyps; Adult; Aged; Biomarkers, Tumor; Case-Control Studies; Colonoscopy; Colorectal Neoplasms; Early Detection of Cancer; Feces; Female; Follow-Up Studies; Humans; Male; Middle Aged; Occult Blood; Prognosis; Pyruvate Kinase; ROC Curve; CA 19-9 antigen; carcinoembryonic antigen; pyruvate kinase isoenzyme type M2 dimer; tumor marker; unclassified drug; abdominal radiography; adenomatous colorectal polyp; Article; blood cell count; body weight loss; cachexia; cancer screening; case control study; clinical article; colon biopsy; controlled study; disease marker; erythrocyte sedimentation rate; histopathology; human; human tissue; occult blood test; pelvis radiography; priority journal; sensitivity and specificity; adenomatous polyp; colorectal tumor; early cancer diagnosis; enzymology; follow up; metabolism; procedures; receiver operating characteristic

Citation Information

Scopus Citations: 13

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