In vitro antischistosomal activity of Allium cepa L. (red onion) extracts and identification of the essential oil composition by GC-MS

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Lateef E.; Rabia I.; Abdel-Gawad M.; El-Sayed M.

Journal: Journal of Microbiology, Biotechnology and Food Sciences

Publisher: Slovak University of Agriculture

Publication Date: 1 February 2018

Volume / Issue: Volume 7 / Issue 4

Pages: 421–425

ISSN: 13385178

DOI: 10.15414/jmbfs.2018.7.4.421-425

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Abdel-Lateef E., Theodor Bilharz Research Institute, Medicinal Chemistry laboratory, Korniash El-Nile, Warrak El-Hadar, Giza, 12661, Egypt; Rabia I., Theodor Bilharz Research Institute, Parasitology Laboratory, Korniash El-Nile, Warrak El-Hadar, Giza, 12661, Egypt; Abdel-Gawad M., Theodor Bilharz Research Institute, Medicinal Chemistry laboratory, Korniash El-Nile, Warrak El-Hadar, Giza, 12661, Egypt; El-Sayed M., Theodor Bilharz Research Institute, Medicinal Chemistry laboratory, Korniash El-Nile, Warrak El-Hadar, Giza, 12661, Egypt

Abstract

Allium cepa L. (red onion) is one of the most famous vegetable crops grown in Egypt due to its medical and nutritional importance. In vitro antischistosomal bioassay of ethyl acetate (EtOAc) and butanolic (BuOH) fractions derived from methanolic (MeOH) extract of A. cepa as well as the essential oil of plant bulbs was carried out using ascending doses. The chemical constituents of essential oil were further investigated using GC-MS analysis. The results revealed that the MeOH extract, EtOAc fraction, BuOH fraction and essential oil have a significant effect on adult Schistosoma mansoni worms. The essential oil of A. cepa gave high worm mortality (%) at the concentration 500 μg/mL (75%), 250 μg/mL (50%) and 125 μg/mL (30%) death rate after 24 hours. GC-MS analysis of A. cepa essential oil exhibited different chemical volatile constituents such as organosulfur compounds, alcohols, acids, esters, furans, phenols, and aldehyde. 3, 5-Diethyl -1, 2, 4-trithiolane (10.17%), 1, 3, 5-trithiolane (7.80%), and 3-(2H-furanone, 2-hexyl-5-methyl) (7.74%) represented the highest contents percent in essential oil of A. cepa bulbs. In conclusion, the bulbs of A. cepa exhibited antischistosomal activities and contain a variety of bioactive chemical constituents and can be considered as a natural antischistosomal agent.

Keywords

Allium cepa L.; Antischistosomal activity; GC-MS analysis

Citation Information

Scopus Citations: 7

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