Parasitological and immunological study of the effect of chitosan and chitosan nanoparticles loaded with spiramycin on toxoplasmosis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamad H.K.; Ramadan N.F.; Mohamed S.H.; Aly I.R.; Zalat R.S.

Journal: Journal of Global Pharma Technology

Publisher: Journal of Global Pharma Technology

Publication Date: 2018

Volume / Issue: Volume 10 / Issue 6

Pages: 138–145

ISSN: 9758542

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Hamad H.K., Biology Department, College of Science forWomen, Baghdad University, Iraq; Ramadan N.F., Zoology Department, Faculty of Science, Ain Shams University, Egypt; Mohamed S.H., Zoology Department, Faculty of Science, Ain Shams University, Egypt; Aly I.R., Parasitology Department, Theodor Bilharz Research Institute, Germany; Zalat R.S., Parasitology Department, Theodor Bilharz Research Institute, Germany

Abstract

This study was carried out to evaluate parasitological and immunological of the effect of chitosan and chitosannanoparticles loaded with spiramycin on toxoplasmosis infected mice. After injection intra peritoneal with 103viable tachyzoites for acute infection, treatments given for seven days. Peritoneal fluid examination revealed a significant decrease in the number of Toxoplasmagondiitachyzoites in all treated infected mice compared with infected non-treated. The combined therapy gave better results than single. The best effect was observed in group of mice treated with spiramycin combined with chitosan nanoparticles. Also immunoglobulin Ig Manti body and gamma Interferon (INFγ), Tumor Necrosis Factor alpha (TNF-α) cytokines responses against T. gondii antigens were assessed by enzyme linked immunosorbent assays (ELISA) kits after treatment. In this study the findings indicated improvement of immune status after treatment. © 2009-2018, JGPT.

Keywords

Cytokines; ELISA; Nanochitosan; Spiramycin; Toxoplasma gondii; chitosan; chitosan nanoparticle; gamma interferon; immunoglobulin M antibody; parasite antigen; tumor necrosis factor; animal experiment; animal model; Article; controlled study; enzyme linked immunosorbent assay; immune response; male; mouse; nonhuman; peritoneal fluid; tachyzoite; toxoplasmosis

Citation Information

Scopus Citations: 6

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