Impact of cyclin D1 and heterogeneous nuclear ribonucleoprotein-K (HnRNP-K) on urinary bladder carcinogenesis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Aboushousha T.; Hammam O.; Helal N.; El Dahshan S.

Journal: Asian Pacific Journal of Cancer Prevention

Publisher: Asian Pacific Organization for Cancer Prevention

Publication Date: 2018

Volume / Issue: Volume 19 / Issue 2

Pages: 513–519

ISSN: 15137368

DOI: 10.22034/APJCP.2018.19.2.513

Scopus: View on Scopus

PubMed: 29480994

Document Type: Article

Authors and Affiliations

Aboushousha T., Pathology Department, Theodor Bilharz Research Institute, Cairo, Egypt; Hammam O., Pathology Department, Theodor Bilharz Research Institute, Cairo, Egypt; Helal N., Pathology Department, Theodor Bilharz Research Institute, Cairo, Egypt; El Dahshan S., Urology Department, Theodor Bilharz Research Institute, Cairo, Egypt

Abstract

Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied the immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladder lesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC) and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to other groups (p < 0.001) and in UC with low grade, non-muscle invasive and papillary tumors compared to their counterparts (p < 0.05, < 0.01 and < 0.05 respectively), however, bilharzial association does not affect cyclin D1 expression. Higher hnRNP-K expression was found in SCC compared to other groups (p < 0.001) and in UC with high grade, muscle invasive and non-papillary tumors compared to their counterparts (p < 0.001each). Bilharzial-associated UC showed higher expression of hnRNP-K percent (p < 0.05) compared to non-bilharzial cases. Conclusion: This study elucidated a possible contribution of cyclin D1 and hnRNP-K expression in the initiation and progression of urinary bladder carcinoma, so, both of them can be used in predicting progression of urinary bladder carcinoma and to differentiate between UC and SCC in high grade tumors. The possible role of both markers in immunotherapy deserves supplementary studies. © 2018, Asian Pacific Organization for Cancer Prevention.

Keywords

Bilharziasis; Bladder cancer; Cyclin D1; HnRNP-K; Immunohistochemistry; Adult; Aged; Biomarkers, Tumor; Carcinogenesis; Disease Progression; Female; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Male; Middle Aged; Muscles; Neoplasm Invasiveness; Urinary Bladder; Urinary Bladder Neoplasms; CCND1 protein, human; heterogeneous nuclear ribonucleoprotein K; tumor marker; bladder; bladder tumor; disease exacerbation; human; metabolism; muscle; pathology; tumor invasion

Citation Information

Scopus Citations: 10

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