Extraction, isolation, and characterization of bioactive compounds and essential oil from Syzygium jambos

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ghareeb M.A.; Hamed M.M.; Abdel-Aleem A.-A.H.; Saad A.M.; Abdel-Aziz M.S.; Hadad A.H.

Journal: Asian Journal of Pharmaceutical and Clinical Research

Publisher: Innovare Academics Sciences Pvt. Ltd

Publication Date: 1 August 2017

Volume / Issue: Volume 10 / Issue 8

Pages: 194–200

ISSN: 9742441

DOI: 10.22159/ajpcr.2017.v10i8.18849

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Ghareeb M.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Hamed M.M., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Abdel-Aleem A.-A.H., Department of Organic Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt; Saad A.M., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Abdel-Aziz M.S., Department of Microbial Chemistry, Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Giza, Egypt; Hadad A.H., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Objectives: Over the past few decades, phenolic compounds become important due to it has been associated with protection against different diseases and sensory point of vision. Hence, at the present study, there has been a growing interest to carry out structural elucidation and characterization of the pure isolates from Syzygium jambos. Methods: S. jambos dried powder leaves were extracted by soaking in 85% methanol solvent at room temperature 25±2°C. The antioxidative activity of the isolates was assessed according to 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and phosphomolybdenum assays. Results: A total of 8 compounds were isolated from the n-butanol extract of S. jambos (Family Myrtaceae) plant, they were identified as quercetin-3-O-rutinoside (1), prenylbenzoic acid 4-β-D-glucoside (2), morolic acid 3-O-caffeate (3), 5,4’-dihydroxy, 7-methoxy, 6-methyl-flavone (4), 3,4,5-trihydroxybenzoic acid (5), quercetin (6), isoetin-7-O-β-D-glucopyranoside (7), and (4’-hydroxy-3’-methoxyphenol-β-D-[6-O-(4”-hydroxy-3”,5”-dimethoxylbenzoate)] glucopyranoside) (8). Compounds 5 and 6 showed the most radical scavengers among the tested compounds with SC50 values of 5.50 and 4.30 µg/ml, respectively, compared to ascorbic acid as standard and the total antioxidant capacity (TAC) values of 605.0 and 680.59 mg ascorbic acid equivalent/g compound, respectively. In vitro antimicrobial activities of the isolated compounds were tested using disc agar plate method against four pathogenic microbial strains including Gram-positive, Gram-negative bacteria and yeast with inhibition zones from 9 to 19 mm. Gas chromatography-mass spectrometry analysis for the essential oil provides twenty four identified components representing 92% of its total oil composition. Conclusion: The results supported that S. jambos could be attributed to sources of natural antioxidant and antimicrobial applications. © 2017 The Authors.

Keywords

Antioxidant compounds; Flavonoids; Natural products; Phenols; Syzygium jambos; 4' hydroxy 3' methoxyphenol beta dextro [6 o (4'' hydroxy 3'',5'' dimethoxylbenzoate)] glucopyranoside; 5,4' dihydroxy 7 methoxy 6 methyl flavone; ascorbic acid; essential oil; gallic acid; isoetin 7 o beta dextro glucopyranoside; methanol; morolic acid 3 o caffeate; plant extract; plant medicinal product; prenylbenzoic acid 4 beta dextro glucoside; quercetin; rutoside; Syzygium jambos extract; unclassified drug; antimicrobial activity; antioxidant activity; Article; Candida albicans; controlled study; DPPH radical scavenging assay; drug isolation; drug structure; dry powder; fractionation; Gram negative bacterium; Gram positive bacterium; hydrolysis; in vitro study; mass fragmentography; methicillin resistant Staphylococcus aureus; nonhuman; plant leaf; Pseudomonas aeruginosa; Staphylococcus aureus; Syzygium

Citation Information

Scopus Citations: 13

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