Potential ultrastructure predicting factors for hepatocellular carcinoma in HCV infected patients

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mansy S.S.; El-Ahwany E.; Mahmoud S.; Hassan S.; Seleem M.I.; Abdelaal A.; Helmy A.H.; Zoheiry M.K.; AbdelFattah A.S.; Hassanein M.H.

Journal: Ultrastructural Pathology

Publisher: Taylor and Francis Ltd

Publication Date: 11 May 2017

Volume / Issue: Volume 41 / Issue 3

Pages: 209–226

ISSN: 1913123

DOI: 10.1080/01913123.2017.1316330

Scopus: View on Scopus

PubMed: 28494215

Document Type: Article

Authors and Affiliations

Mansy S.S., Electron Microscopy Research Department (Pathology), Theodor Bilharz Research Institute, Giza, Egypt; El-Ahwany E., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt; Mahmoud S., Parasitology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hassan S., Electron Microscopy Research Department (Pathology), Theodor Bilharz Research Institute, Giza, Egypt; Seleem M.I., Hepatobiliary Surgery and Liver Transplantation, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Abdelaal A., Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Helmy A.H., Surgery Department, Theodor Bilharz Research Institute, Giza, Egypt; Zoheiry M.K., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt; AbdelFattah A.S., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hassanein M.H., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Hepatitis C virus represents one of the rising causes of hepatocellular carcinoma (HCC). Although the early diagnosis of HCC is vital for successful curative treatment, the majority of lesions are diagnosed in an irredeemable phase. This work deals with a comparative ultrastructural study of experimentally gradually induced HCC, surgically resected HCC, and potential premalignant lesions from HCV-infected patients, with the prospect to detect cellular criteria denoting premalignant transformation. Among the main detected pathological changes which are postulated to precede frank HCC: failure of normal hepatocyte regeneration with star shape clonal fragmentation, frequent elucidation of hepatic progenitor cells and Hering canals, hepatocytes of different electron density loaded with small sized rounded monotonous mitochondria, increase junctional complexes bordering bile canaliculi and in between hepatocyte membranes, abundant cellular proteinaceous material with hypertrophied or vesiculated rough endoplasmic reticulum (RER), sequestrated nucleus with proteinaceous granular material or hypertrophied RER, formation of lipolysosomes, large autophagosomes, and micro-vesicular fat deposition. In conclusion, the present work has visualized new hepatocytic division or regenerative process that mimic splitting or clonal fragmentation that occurs in primitive creature. Also, new observations that may be of value or assist in predicting HCC and identifying the appropriate patient for surveillance have been reported. Moreover, it has pointed to the possible malignant potentiality of liver stem/progenitor cells. For reliability, the results can be subjected to cohort longitudinal study. © 2017 Taylor & Francis.

Keywords

Experimental HCC; hepatic progenitor cell; hepatocellular carcinoma; liver regenerative nodules; liver stem/progenitor cells; oval cell; Carcinoma, Hepatocellular; Diagnosis, Differential; Female; Hepatitis C; Hepatocytes; Humans; Liver Neoplasms; Male; Reproducibility of Results; Stem Cells; complication; differential diagnosis; human; liver cell; liver cell carcinoma; liver tumor; reproducibility; stem cell; ultrastructure; virology

Citation Information

Scopus Citations: 6

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