Expression of FGFR3 protein and gene amplification in urinary bladder lesions in relation to schistosomiasis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hammam O.; Aboushousha T.; El-Hindawi A.; Khairy H.; Khalil H.; Kamel A.; Akl M.; Abdel-Hady A.; Magdy M.; Badawy M.; El Kholy A.; Al Osili K.; Kamel N.; Anis S.; El Leithy T.

Journal: Open Access Macedonian Journal of Medical Sciences

Publication Date: 8 April 2017

Volume / Issue: Volume 5 / Issue 2

Pages: 160–166

ISSN: 18579655

DOI: 10.3889/oamjms.2017.048

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Hammam O., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Aboushousha T., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; El-Hindawi A., Faculty of Medicine Cairo University, Cairo, Egypt; Khairy H., Faculty of Medicine Cairo University, Cairo, Egypt; Khalil H., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Kamel A., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Akl M., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Abdel-Hady A., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Magdy M., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Badawy M., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; El Kholy A., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Al Osili K., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt; Kamel N., National Research Center5, El Doki, Giza, Egypt; Anis S., Faculty of Medicine Cairo University, Cairo, Egypt; El Leithy T., Theodor Bilharz Research Institute, Imbaba, Giza, Cairo, Egypt

Abstract

BACKGROUND: Bladder cancer represents the fifth most common malignancy worldwide and a major cause of cancer-related morbidity and death. Incidence and mortality rates have remained relatively constant over the past four decades. Urothelial bladder cancers have identified multiple risk factors. AIM: We aimed at evaluating the expression of the FGFR3 protein and gene amplification in the urothelial cells of neoplastic and non-neoplastic urothelial lesions of the urinary bladder, and correlation with tumour grade, stage and associated bilharziasis. MATERIAL AND METHODS: One hundred and five different urinary bladder lesions were studied, including 15 cystitis cases (9 bilharzial and 6 non-bilharzial cystitides), 75 urothelial carcinoma cases (18 bilharzial associated and 57 non-bilharzial associated) and 15 squamous cell carcinoma associated with bilharziasis, beside 5 control cases. Data concerning age, sex, tumour grade, stage, and associated bilharziasis were obtained. Each case was studied for FGFR3 expression, and FISH technique was applied on forty malignant cases that show high protein expression. RESULTS: The highest incidence of cystitis was in the fourth decade while of bladder cancer was in the seventh decade. Tumour grade was correlated significantly with tumour stage. FGFR3 correlates significantly with tumour grade, stage and with a bilharzial infestation. FGFR3 gene amplification was reported mainly in low grade and NNMBIC tumours. CONCLUSIONS: FGFR3 overexpression in malignant cases was significantly higher than in chronic cystitis. FGFR3 gene amplification was reported mainly in low grade and NNMBIC tumours. FGFR3 may be further studied as a subject for target therapy of bladder cancer. © 2017 Olfat Hammam, Tarek Aboushousha, Ali El-Hindawi, Hosni Khairy, Heba Khalil, Amira Kamel, Maha Akl, Ahmed Abdel-Hady, Mona Magdy, Mohamed Badawy, Amr El Kholy, Khalid Al Osili, Nora Kamel, Shady Anis, Tarek El Leithy.

Keywords

Carcinoma; Cystitis; FGFR3; FISH; IHC; Urothelial bladder lesions; fibroblast growth factor receptor 3; adult; age distribution; aged; Article; bladder injury; cancer grading; cancer staging; controlled study; female; FGFR3 gene; fluorescence in situ hybridization; gene; gene amplification; gene overexpression; genetic association; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; microphotography; middle aged; muscle invasive bladder cancer; protein expression; schistosomiasis; sex ratio; squamous cell carcinoma; transitional cell carcinoma

Citation Information

Scopus Citations: 7

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