Expression of epidermal growth factor receptor and transforming growth factor alpha in cancer bladder: Schistosomal and non-schistosomal

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Badawy A.A.; El-Hindawi A.; Hammam O.; Moussa M.; Helal N.S.; Kamel A.

Journal: Current Urology

Publisher: S. Karger AG

Publication Date: January 2017

Volume / Issue: Volume 9 / Issue 4

Pages: 192–201

ISSN: 16617649

DOI: 10.1159/000447140

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Badawy A.A., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt; El-Hindawi A., Department of Pathology, Faculty of Medicine, Cairo University, Giza, Egypt; Hammam O., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt; Moussa M., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt; Helal N.S., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt; Kamel A., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Imbaba, Giza, Egypt

Abstract

Introduction: Overexpression of epidermal growth factor receptor (EGFR) has been described in several solid tumors including bladder cancer. Transforming growth factor alpha (TGFα) is frequently deregulated in neoplastic cells and plays a role in the development of bladder cancer. TGFα-EGFR ligand-receptor combination constitutes an important event in multistep tumorigenesis. Methods: This study was done on 30 bladder biopsies from patients with urothelial carcinoma, 15 with squamous cell carcinoma, 10 with cystitis and 5 normal control bladder specimens. All were immuohistochemically stained with EGFR and TGFα antibodies. Results: EGFR and TGFα were over-expressed in higher grades and late stages of bladder cancer. Moreover, they show higher expression in squamous cell carcinoma compared to urothelial carcinoma and in schistosomal associated lesions than in non-schistosomal associated lesions. Conclusion: EGFR and TGFα could be used as prognostic predictors in early stage and grade of bladder cancer cases, especially those with schistosomal association. In addition they can help in selecting patients who can get benefit from anti-EGFR molecular targeted therapy. © 2015 S. Karger AG, Basel.

Keywords

Bladder cancer; Epidermal growth factor receptor; Immunohistochemistry; Schistosomiasis; Transforming growth factor-α; transforming growth factor alpha; adult; aged; Article; bladder biopsy; cancer grading; cancer staging; carcinogenesis; controlled study; cystitis; disease association; female; histopathology; human; human tissue; major clinical study; male; muscle invasive bladder cancer; priority journal; protein expression; Schistosoma; schistosomal carcinoma; schistosomal cystitis; scoring system; squamous cell carcinoma; transitional cell carcinoma

Citation Information

Scopus Citations: 10

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