In vitro screening of BTP-Iso on Schistosoma mansoni and its intermediate host Biomphalaria alexandrina

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Taman A.; El-Beshbishi S.N.; Bardicy S.E.; Tadros M.; Ayoub M.; Mansour B.; El-Bialy S.

Journal: Asian Pacific Journal of Tropical Disease

Publisher: Elsevier B.V.

Publication Date: December 2016

Volume / Issue: Volume 6 / Issue 12

Pages: 946–951

ISSN: 22221808

DOI: 10.1016/S2222-1808(16)61162-3

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Taman A., Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt; El-Beshbishi S.N., Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt; Bardicy S.E., Department of Medical Malacology, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Tadros M., Department of Medical Malacology, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Ayoub M., Department of Medical Malacology, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Mansour B., Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; El-Bialy S., Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

Abstract

Objective To test the effect of benzimidazole-derived compound (compound BTP-Iso) on cultured adult Schistosoma mansoni and clean Biomphalaria alexandrina snails. Methods Adult schistosomes were incubated at different concentrations of compound BTP-Iso to calculate mortality rate, LC90 and LC50, in addition, tegumental changes were recorded using SEM. Clean Biomphalaria alexandrina snails were also incubated with compound BTP-Iso at various concentrations to report snail mortality. Results Compound BTP-Iso was found to possess potent antischistosomal activities on adult worms but no effect was recorded on snail host. At a concentration of 8 μg/mL, mortality rates were 45.8% and 81.0% after 48 h and 72 h incubation, respectively, while 100% mortality was recorded after 48 h incubation at 20.0 μg/mL and after 72 h incubation at 10.0 μg/mL, with LC50 and LC90 of 6.1 μg/mL and 9.8 μg/mL, respectively. Morphological changes and tegumental alternation of treated worms suggested loss of the tegument and its vital functions. Conclusions This study provided the evidence for the potential antischistosomal effect of compound BTP-Iso and its possible uses as an alternative chemotherapeutic agent for treatment of schistosomiasis. © 2016 Asian Pacific Tropical Medicine Press

Keywords

Benzimidazoles; In vitro; Schistosoma mansoni; Snail; Tegument; Tubulin; antischistosomal agent; btp iso; praziquantel; unclassified drug; adult; antischistosomal activity; Article; Biomphalaria alexandrina; controlled study; drug activity; drug effect; drug efficacy; drug potency; drug screening; female; in vitro study; LC50; LC90; male; mortality rate; muscle contraction; nonhuman; priority journal; scanning electron microscopy; sex difference; worm tegument

Citation Information

Scopus Citations: 7

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