Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdallah E.; El-Shishtawy S.; Sherif N.; Ali A.; El-Bendary O.

Journal: International Urology and Nephrology

Publisher: Springer Netherlands

Publication Date: 23 November 2016

Volume / Issue: Volume 49 / Issue 2

Pages: 329–335

ISSN: 3011623

DOI: 10.1007/s11255-016-1465-y

Scopus: View on Scopus

PubMed: 27878751

Document Type: Article

Authors and Affiliations

Abdallah E., Department of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt; El-Shishtawy S., Department of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt; Sherif N., Department of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt; Ali A., Department of Intensive Care Unit, Theodor Bilharz Research Institute, Cairo, Egypt; El-Bendary O., Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt

Abstract

Purpose: Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. Methods: This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease. Serum levels for lipid profiles, C-reactive protein, calcium, phosphate, and parathyroid hormone were measured. PON-1 activity was also measured and compared to the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Echocardiography was used to measure EAT thickness (EATT). The correlation between PON-1 and EATT was assessed, while independent predictors of EATT in HD patients were similarly assessed using multivariate regression analysis. Results: There was a significant low mean value of PON-1 activity in HD patients compared with the control group (82.1 ± 31.6 vs. 164.3 ± 61.5 U/l, p = 0.0001) and significant high mean value of EATT in HD patients, compared with controls (6.2 ± 1.7 vs. 3.9 ± 1.1 mm, p = 0.0001). In addition, there was a significant negative correlation between PON-1 activity and EATT (r = −0.484, p = 0.0001) and a significant positive correlation between PON-1 activity and HDL-C (r = 0.417, p = 0.0003). PON-1, total cholesterol, triglycerides, LDL, HDL, age, and body mass index were found to be independent predictors of EATT. Conclusion: Our study demonstrated that PON-1 activity was significantly lower in HD patients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population. © 2016, Springer Science+Business Media Dordrecht.

Keywords

Epicardial adipose tissue; Hemodialysis; Paraoxonase-1 activity; Adipose Tissue; Adult; Aryldialkylphosphatase; Biomarkers; Body Mass Index; Cross-Sectional Studies; Echocardiography; Egypt; Female; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Middle Aged; Nitrophenols; Pericardium; Renal Dialysis; Statistics as Topic; 4 nitrophenol; aryldialkylphosphatase 1; C reactive protein; calcium; cholesterol; high density lipoprotein; high density lipoprotein cholesterol; low density lipoprotein; paraoxon; parathyroid hormone; phosphate; triacylglycerol; 4-nitrophenol; biological marker; nitrophenol; age; Article; body mass; controlled study; cross-sectional study; end stage renal disease; enzyme activity; enzyme blood level; epicardial fat; hemodialysis patient; human; hydrolysis; major clinical study; blood; metabolism; pathology; procedures; statistics

Citation Information

Scopus Citations: 15

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