Evaluating the association of interleukin-10 gene promoter -592 A/C polymorphism with lupus nephritis susceptibility

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdallah E.; Waked E.; Abdelwahab M.A.

Journal: Kidney Research and Clinical Practice

Publisher: Elsevier B.V.

Publication Date: March 2016

Volume / Issue: Volume 35 / Issue 1

Pages: 29–34

ISSN: 22119132

DOI: 10.1016/j.krcp.2015.11.002

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Abdallah E., Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt; Waked E., Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt; Abdelwahab M.A., Department of Medical Biochemistry, Faculty of Medicine, Fayoum University, Faiyum, Egypt

Abstract

Background Interleukin-10 (IL-10) is an important immunoregulatory cytokine. There are few studies evaluating the association between IL-10 and lupus nephritis (LN). The aim of this study was to evaluate the association of IL-10 gene promoter -592 A/C with LN susceptibility. Methods The study was conducted on 84 patients with systemic lupus erythematosus (SLE). Patients were divided into LN group (Group I, 48 patients) and non-LN group (Group II, 36 patients). The -592 A/C polymorphisms in IL-10 promoter gene were determined by polymerase chain reaction and restriction fragment length polymorphism in both groups. IL-10 was determined by enzyme-linked immunosorbent assay. Frequencies of the genotypes were compared between LN and non-LN patients and among LN patients with different pathologic classes. Results There was a significant increase in serum level of IL-10 (P = 0.001) in Group I compared with Group II and significant positive correlation between serum IL-10 and SLE disease activity index (r = 0.466, P = 0.001) in Group I. There were no significant differences in the distribution of the IL-10 gene promoter -592 A/C genotypes or the allele frequencies between Groups I and II. There was no significant difference between AC/CC and AA genotypes with SLE disease activity index, proteinuria, hematuria, anti-double-stranded DNA, and IL-10 in Group I. There was no significant difference in the distribution of AC and CC genotypes among different pathologic LN classes. Conclusion IL-10 suggested to play a role in pathogenesis and development of LN. However, the promoter -592 A/C of IL-10 gene suggested to be not associated with serum IL-10 levels or LN susceptibility. In addition, it appears that promoter -592 A/C of IL-10 gene not associated with LN activity or the pathologic classes of LN. © 2016. The Korean Society of Nephrology. Published by Elsevier.

Keywords

Lupus nephritis; Promoter -592 A/C of interleukin-10 gene; Systemic lupus erythematosus; double stranded DNA antibody; interleukin 10; adult; Article; controlled study; disease predisposition; DNA polymorphism; Egyptian; female; gene frequency; gene identification; genetic association; hematuria; human; human tissue; IL 10 gene; immunopathogenesis; lupus erythematosus nephritis; major clinical study; male; priority journal; protein blood level; proteinuria

Citation Information

Scopus Citations: 15

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