Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El-Din S.H.S.; El-Lakkany N.M.; Salem M.B.; Hammam O.A.; Saleh S.; Botros S.S.

Journal: Journal of Advanced Pharmaceutical Technology and Research

Publisher: Wolters Kluwer Medknow Publications

Publication Date: 2016

Volume / Issue: Volume 7 / Issue 3

Pages: 99–104

ISSN: 22314040

DOI: 10.4103/2231-4040.184594

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

El-Din S.H.S., Department of Pharmacology, Theodor Bilharz Research Institute, Warak El-Hadar, P.O. Box: 30, Imbaba, Giza, 12411, Egypt; El-Lakkany N.M., Department of Pharmacology, Theodor Bilharz Research Institute, Warak El-Hadar, P.O. Box: 30, Imbaba, Giza, 12411, Egypt; Salem M.B., Department of Pharmacology, Theodor Bilharz Research Institute, Warak El-Hadar, P.O. Box: 30, Imbaba, Giza, 12411, Egypt; Hammam O.A., Department of Pathology, Theodor Bilharz Research Institute, Warak El-Hadar, Imbaba, Giza, 12411, Egypt; Saleh S., Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Botros S.S., Department of Pharmacology, Theodor Bilharz Research Institute, Warak El-Hadar, P.O. Box: 30, Imbaba, Giza, 12411, Egypt

Abstract

Resveratrol is a naturally occurring polyphenol, possesses several pharmacological activities including anticancer, antioxidant, antidiabetic, antinociceptive, and antiasthmatic activity. Little is known about its hepatoprotective action mechanisms. This study was conceived to explore the possible protective mechanisms of resveratrol compared with the hepatoprotective silymarin in thioacetamide (TAA)-induced hepatic injury in rats. Thirty-two rats were equally divided into four groups; normal control (i), TAA (100 mg/kg) (ii), TAA + silymarin (50 mg/kg) (iii), and TAA + resveratrol (10 mg/kg) (iv). Liver function and histopathology, pro-inflammatory cytokines, oxidative stress, and apoptotic markers were examined. Data were analyzed using ANOVA test followed by Tukey post hoc test. Compared to TAA-intoxicated group, resveratrol mitigated liver damage, and inflammation as noted by less inflammatory infiltration, hydropic degeneration with decreased levels of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma by 78.83, 18.12, and 64.49%, respectively. Furthermore, it reduced (P < 0.05) alanine and aspartate aminotransferases by 36.64 and 48.09%, respectively, restored hepatic glutathione content and normalized superoxide dismutase and malondialdehyde levels. While it inhibited nuclear factor-kappa B, cytochrome 2E1, and enhanced apoptosis of necrotic hepatocytes via increasing caspase-3 activity. Our findings indicated that the potential hepatoprotective mechanisms of resveratrol are associated with inhibition of inflammation, enhancing the apoptosis of necrotic hepatocytes, and suppression of oxidative stress. © 2016 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer - Medknow.

Keywords

Caspase-3; Cytotoxicity; Liver inflammation; Pro-inflammatory cytokines; Resveratrol; alanine aminotransferase; aspartate aminotransferase; caspase 3; cytochrome P450 2E1; gamma interferon; glutathione; immunoglobulin enhancer binding protein; interleukin 6; malonaldehyde; silymarin; superoxide dismutase; tumor necrosis factor alpha; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; apoptosis; Article; controlled study; drug mechanism; enzyme activity; histopathology; in vitro study; liver cell; liver function; liver injury; liver protection; nonhuman; outcome assessment; oxidative stress; priority journal; rat

Citation Information

Scopus Citations: 24

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