Evaluation of Echinostoma liei worm, metacercaria and redia antigens for schistosomiasis control

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Monaem G.; Farid A.; Rabia I.; El-Amir A.

Journal: Experimental Parasitology

Publisher: Academic Press Inc.

Publication Date: October 2015

Volume / Issue: Volume 157

Pages: 23–29

ISSN: 144894

DOI: 10.1016/j.exppara.2015.06.008

Scopus: View on Scopus

PubMed: 26115938

Document Type: Article

Authors and Affiliations

Abdel-Monaem G., Zoology Dept., Faculty of Science, Cairo University, Giza, Egypt; Farid A., Zoology Dept., Faculty of Science, Cairo University, Giza, Egypt; Rabia I., Parasitology Dept., Theodore Bilharz Research Institute, Giza, Egypt; El-Amir A., Zoology Dept., Faculty of Science, Cairo University, Giza, Egypt

Abstract

While chemotherepeutic drugs, such as praziquantel, oxamniquine and metrifonate, are currently considered safe and effective drugs for schistosomiasis treatment, reinfection occurs frequently after drug treatment. Thus, a vaccine is sought to provide long-term treatment. Antigens from worm, metacercaria and redia of Echinostoma liei (E. liei) were purified using CNBr-activated Sepharose column, then used for immunization of mice prior to infection with Schistosomiasis mansoni. Worm burden, hepatic and intestinal eggs and oogram count was significantly reduced and that was reflected in normalization of liver architecture. This referred to a significant increase in the tested immunoglobulin level (IgM, IgG1 and IgG2). © 2015 Elsevier Inc.

Keywords

Echinostomaliei; Immunoglobulins; Oogram; PZQ; Schistosomiasis; Worm burden; Animals; Antibodies, Helminth; Antigens, Helminth; Biomphalaria; Echinostoma; Female; Immunoglobulin G; Intestines; Liver; Male; Mice; Parasite Egg Count; Schistosoma mansoni; Schistosomiasis mansoni; Vaccines; Echinostoma liei; Mus; Echinostoma liei antigen; immunoglobulin G1; immunoglobulin G2; immunoglobulin M; parasite antigen; Schistosoma vaccine; unclassified drug; helminth antibody; vaccine; animal cell; animal experiment; animal model; animal tissue; Article; cell count; controlled study; immunization; infection control; liver architecture; metacercaria; mouse; nonhuman; oogram count; priority journal; tissue structure; worm; worm egg; animal; blood; growth, development and aging; immunology; intestine; parasite identification; parasitology

Citation Information

Scopus Citations: 4

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