Glyphosate herbicide induces genotoxic effect and physiological disturbances in Bulinus truncatus snails

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Bakry F.A.; Ismail S.M.; Abd El-Atti M.S.

Journal: Pesticide Biochemistry and Physiology

Publisher: Academic Press Inc.

Publication Date: September 2015

Volume / Issue: Volume 123

Pages: 24–30

ISSN: 483575

DOI: 10.1016/j.pestbp.2015.01.015

Scopus: View on Scopus

PubMed: 26267049

Document Type: Retracted

Authors and Affiliations

Bakry F.A., Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Ismail S.M., Zoology Department, Faculty of Science, Cairo University, Giza, Egypt; Abd El-Atti M.S., Department of zoology, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

Herbicides are being used in agriculture for controlling noxious weed. Glyphosate is a herbicide that is widely applied to cereal crops in Egypt and is used in controlling a very broad spectrum of weeds. The present study was designed to investigate the response of the snail Bulinus truncatus as a bioindicator for physiological and molecular aspects of B. truncatus snails after exposure to sublethal concentrations of glyphosate for two weeks. In treating snails, glucose concentration (GL) in the haemolymph as well as lactate (LT) in soft tissues of treated snails increased, while glycogen (GN), pyruvate (PV), total protein (TP), nucleic acids (DNA and RNA) levels in snail's tissues decreased. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR), thioredoxin reductase (TrxR), glycogen phosphorylase (GP), glucose-6-phosphatase (G-6-Pase), succinic dehydrogenase (SDH) and lactic dehydrogenase (LDH) enzymes in homogenate of snail's tissues were reduced in response to the treatment with the herbicide, while lipid peroxide (LP), sorbitol dehydrogenase (SDH) and transaminases (GOT and GPT) activity increased (P < 0.001). The changes in the number, position and intensity of DNA bands induced by glyphosate herbicide may be attributed to the fact that the herbicide can induce genotoxicity through DNA damage. Thus, the present result indicated that the genotoxicity products at low concentration and for long time treatment showed the hazard of herbicide addiction on man's life. © 2015 Elsevier Inc.

Keywords

Bulinus truncatus snails; Glyphosate herbicide; Molecular genetic; The physiological effects; Animals; Bulinus; Catalase; DNA Damage; Glutathione Reductase; Glycine; Glycogen Phosphorylase; Herbicides; Lipid Peroxides; Superoxide Dismutase; Thioredoxin-Disulfide Reductase; Transaminases; Bulinus truncatus; Gastropoda; aminotransferase; glyphosate; herbicide; lipid peroxide; thioredoxin reductase; analogs and derivatives; animal; drug effects; metabolism; physiology

Citation Information

Scopus Citations: 17

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