Combined Vaginal Pelvic Floor Electrical Stimulation (PFS) and Local Vaginal Estrogen for Treatment of Overactive Bladder (OAB) in Perimenopausal Females. Randomized Controlled Trial (RCT)

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdelbary A.M.; El-Dessoukey A.A.; Massoud A.M.; Moussa A.S.; Zayed A.S.; Elsheikh M.G.; Ghoneima W.; Abdella R.; Yousef M.

Journal: Urology

Publisher: Elsevier Inc.

Publication Date: September 2015

Volume / Issue: Volume 86 / Issue 3

Pages: 482–486

ISSN: 904295

DOI: 10.1016/j.urology.2015.06.007

Scopus: View on Scopus

PubMed: 26135813

Document Type: Article

Authors and Affiliations

Abdelbary A.M., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; El-Dessoukey A.A., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Massoud A.M., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Moussa A.S., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Zayed A.S., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Elsheikh M.G., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Ghoneima W., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Abdella R., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt; Yousef M., Department of Urology, Beni-Suef University, Beni-Suef, Egypt; the Department of Urology, Theodor Bilharz Research Institute, Giza, Egypt; the Department of Urology, Cairo University, Cairo, Egypt; and the Department of Obstetric and Gynecology, Cairo University, Giza, Egypt

Abstract

Objective To evaluate the efficacy of combined vaginal pelvic floor electrical stimulation (PFS) and local vaginal estrogen in treatment of female overactive bladder (OAB). Material and Methods This is a randomized controlled trial carried out on 315 perimenopausal females with OAB who were randomly allocated into 3 equal groups. Group A underwent PFS using vaginal probes twice weekly for 12 sessions. Group B received local vaginal estrogen, whereas group C received both PFS and local estrogen. All patients were evaluated by a voiding diary, quality-of-life questionnaire, vaginal examination, urine analysis, blood sugar, ultrasonography, and urodynamic study before and after therapy. Patients were followed up 1 week, 3, and 6 months post-therapy. The analyzed variables included day and night time frequency, incontinence episodes, urgency, quality of life, detrusor overactivity), and functional bladder capacity). Outcome measure was urge incontinence. Results Within each group, there was a statistically significant improvement in all variables after treatment. Improvement of urgency was better in group C than in groups A and B (P =.000,.009). Improvement of incontinence was better in groups A and C than in group B (P =.005,.004). Follow-up showed worsening of symptoms within 6 months in all groups except incontinence in group C. Conclusion Vaginal PFS and estrogen found to be effective in treating OAB symptoms in perimenopausal females. Estrogen seems to augment the effect of PFS especially in the treatment of urgency incontinence and can delay its recurrence. © 2015 Elsevier Inc. All Rights Reserved.

Keywords

Adult; Aged; Combined Modality Therapy; Electric Stimulation Therapy; Estrogens; Estrogens, Conjugated (USP); Female; Humans; Middle Aged; Pelvic Floor; Perimenopause; Treatment Outcome; Urinary Bladder, Overactive; estrogen; conjugated estrogen; Article; bladder capacity; climacterium; clinical evaluation; controlled study; cream; drug efficacy; echography; electrostimulation therapy; follow up; glucose blood level; human; major clinical study; micturition; nocturia; outcome assessment; overactive bladder; priority journal; quality of life; quality of life assessment; questionnaire; randomized controlled trial; urge incontinence; urinalysis; urinary urgency; urine incontinence; urodynamics; vaginal pelvic floor electrical stimulation; multimodality cancer therapy; pelvis floor

Citation Information

Scopus Citations: 25

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