Impact of epidermal growth factor receptor and transforming growth factor-α on hepatitis C virus-induced hepatocarcinogenesis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Badawy A.A.-G.; El-Hindawi A.; Hammam O.; Moussa M.; Gabal S.; Said N.

Journal: APMIS

Publisher: Blackwell Munksgaard

Publication Date: 17 August 2015

Volume / Issue: Volume 123 / Issue 10

Pages: 823–831

ISSN: 9034641

DOI: 10.1111/apm.12431

Scopus: View on Scopus

PubMed: 26279457

Document Type: Review

Authors and Affiliations

Badawy A.A.-G., Department of Pathology, Theodor Bilharz Research Institute, Imbaba, Egypt; El-Hindawi A., Faculty of Medicine, Cairo University, Giza, Egypt; Hammam O., Department of Pathology, Theodor Bilharz Research Institute, Imbaba, Egypt; Moussa M., Department of Pathology, Theodor Bilharz Research Institute, Imbaba, Egypt; Gabal S., Faculty of Medicine, Cairo University, Giza, Egypt; Said N., Department of Pathology, Theodor Bilharz Research Institute, Imbaba, Egypt

Abstract

Epidermal growth factor receptor system plays a central hepato-protective and pro-regenerative role in liver. Transforming growth factor-α (TGF-α) is an important autocrine growth regulator of hepatocytes that plays a role in development of hepatocellular carcinoma (HCC) among patients with chronic hepatitis C (CHC). This study was done on 40 core liver biopsies from patients with CHC, 20 liver specimens from HCC cases on top of CHC as well as five normal controls. All were immunohistochemically stained with epidermal growth factor receptor (EGFR) and TGF-α antibodies. Some selected HCC cases were submitted for FISH technique to detect EGFR gene alteration. By immunohistochemistry EGFR and TGF-α were overexpressed in HCC and cirrhotic cases compared to CHC cases without cirrhosis. Also, their expression was stronger in CHC cases with higher grades of activity and stages of fibrosis compared to lower ones. FISH positive results for EGFR were detected in 33.3% of the examined HCC cases. EGFR and TGF-α can be used as predictive markers for activity, fibrosis, and carcinogenesis in CHC patients. Overexpression of EGFR in HCC patients can be promising in selecting those who can get benefit from anti-EGFR target therapy. © 2015 APMIS Published by John Wiley & Sons Ltd.

Keywords

Chronic hepatitis C; Epidermal growth factor receptor; Fluorescence in situ hybridization; Immunohistochemistry; Transforming growth factor-α; Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Female; Hepacivirus; Hepatitis C, Chronic; Hepatocytes; Humans; In Situ Hybridization, Fluorescence; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Receptor, Epidermal Growth Factor; Transforming Growth Factor alpha; EGFR protein, human; tumor marker; clinical article; clinical assessment; comparative study; controlled study; gene overexpression; Hepatitis C virus; histopathology; human; human tissue; immunoreactivity; liver biopsy; liver carcinogenesis; liver cell carcinoma; liver fibrosis; liver protection; molecularly targeted therapy; mutation; priority journal; protein expression; Review; genetics; liver cell; liver tumor; metabolism; pathogenicity; virology

Citation Information

Scopus Citations: 25

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