Evaluation of antimicrobial activity of some compounds isolated from Rhamnus cathartica L

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamed M.M.; Refahy L.A.; Abdel-Aziz M.S.

Journal: Oriental Journal of Chemistry

Publisher: Oriental Scientific Publishing Company

Publication Date: 20 June 2015

Volume / Issue: Volume 31 / Issue 2

Pages: 1133–1140

ISSN: 0970020X

DOI: 10.13005/ojc/310266

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Hybrid Gold Open Access

Authors and Affiliations

Hamed M.M., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Refahy L.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Abdel-Aziz M.S., Department of Microbial Chemistry, National Research Center, Dokki, Cairo, Egypt

Abstract

A new anthraquinone derivative, 1,8-dihydroxy-2-[(z)-4-methylpenta-1,3-dien-1-yl] anthraquinone (1), together with known anthraquinone compounds were defined to be, 2-acetyl-3,8-dihydroxy-6-methoxyanthraquinone (2), emodin (3), glucofrangulin A (4) and phenanthrene derivative named dendrochrysanene (5), lactone compounds named [β-sorigenin (6) and geshoidin (7)], xanthone compound termed pruniflorone H (8), oxanthrone compound named rumejaposide I (9), flavonol compounds called [kaempferol (10) and quercetin (11)] have been isolated from the methanolic extract of Rhamnus cathartica L. All isolated compounds were obtained for the first time from the genus Rhamnus cathartica L. except emodin; they were subjected to antimicrobial activity test; compounds (1), (3), (9) exhibited antibacterial activity [G+ve, G-ve] and anti-yeast activity, whereas, compounds (5), (11) exhibited antibacterial activity [G+ve and G-ve]. But, compounds (2), (4), (7), (10) exhibited antibacterial activity G-ve while compounds (6), (8) exhibited antibacterial activity G-ve and anti-yeast activity. The isolated compounds were confirmed by detailed analysis of their 1H, 13CNMR, mass spectral data and by the results of hydrolytic cleavage.

Keywords

Antimicrobial activity; Flavonol; Plant extract; Rhamnus cathartica L.

Citation Information

Scopus Citations: 24

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