Total phenolic, in vitro antioxidant activity and safety assessment (acute, sub-chronic and chronic toxicity) of industrial Taif rose water by-product in mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Hameed E.-S.S.; Bazaid S.A.; Sabra A.A.

Journal: Der Pharmacia Lettre

Publisher: Scholars Research Library

Publication Date: 2015

Volume / Issue: Volume 7 / Issue 2

Pages: 251–259

ISSN: 9755071

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Abdel-Hameed E.-S.S., Natural Products Analysis Laboratory, Faculty of Science, Taif University, Saudi Arabia, Chemistry Department, Faculty of Science, Taif University, Saudi Arabia, Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Bazaid S.A., Natural Products Analysis Laboratory, Faculty of Science, Taif University, Saudi Arabia; Sabra A.A., Laboratory of Pharmacology, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

The by-products or residues of agriculture industries have been taken more attention for their valuable source of natural antioxidants in recent decades. In this work, the Taif rose water by-product obtained after hydro-distillation of Taif rose (Rosa damascena trigintipetala Dieck) was investigated for its biological and phytochemical properties. The results showed that the Taif rose water byproduct had free radical scavenging activity toward artificial 1,1-diphenyl picrylhydrazyl (DPPH•) radical with SC50= 23.72±0.36 mg/ml and also had high antioxidant capacity (329.53±18.75 mg ascorbic acid equivalent/g dry extract) and reducing power activity (211.31±2.79 mg ascorbic acid equivalent/g dry extract). Phenolic compounds are the major components and the antioxidant properties were attributed to them. The direct infusion ESI(-ve)-MS analyses of Taif rose water by-product showed the presence of phenolic compounds belonging to hydrolysable tannins and flavonoids. The acute, sub-chronic and chronic toxicity studies of Taif rose water by-product in mice suggested that it was safe and not toxic. From this work, it is obvious that the water by-product obtained after hydro-distillation of Taif rose could be used as a good natural inexpensive source of antioxidant polyphenolics after more phytochemical, in vitro and in vivo studies.

Keywords

Antioxidant; ESI(-ve)-MS; Industrial taif rose water byproduct; Phenolics; Sub-chronic and chronic toxicity; 1,1 diphenyl 2 picrylhydrazyl; ascorbic acid; flavonoid; flavonol derivative; free radical; gallic acid; natural product; phenol derivative; plant medicinal product; Taif rose water byproduct; tannin derivative; unclassified drug; acute toxicity; adult; animal experiment; animal model; animal tissue; antioxidant activity; Article; chronic toxicity; controlled study; drug hydrolysis; drug safety; drug screening; hydrodistillation; in vitro study; LD 50; male; mouse; nonhuman

Citation Information

Scopus Citations: 15

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