Molluscicidalactivity of some constituents isolated from Cestrum purpureum

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamed M.; El-Amin S.; Abdel-Fattah A.S.

Journal: Pharmacologyonline

Publisher: SILAE (Italo-Latin American Society of Ethnomedicine)

Publication Date: 2015

Volume / Issue: Volume 2

Pages: 59–72

ISSN: 18278620

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Hamed M., Medicinal Chemistry Department, Theodor BilharzResearch Institute, Giza, Egypt; El-Amin S., Medicinal Chemistry Department, Theodor BilharzResearch Institute, Giza, Egypt; Abdel-Fattah A.S., Organic Chemistry department, Cairo University, Giza, Egypt

Abstract

Purified compounds of Cestrum purpureum (family: Solanaceae), were used as plant molluscicides against the vector snails Biomphalaria alexandrina. Phytochemical screening tests aiming at identification of the different groups of the constituents of Cestrum purpureum were carried out and the results showed that the plant contains glycosides, sterols, saponins, tannins and flavonoids where alkaloids are absent. Three compounds were isolated from Cestrum purpureum by using silica gel column chromatography and thin layer chromatography and could be identified using spectroscopic analysis (IR, 1HNMR, 13CNMR and chemical ionization mass spectrum) and hydrolysis to be compound (1) was ursolic acid, compound (2) was 3-O-β-Dglucopyranosyl-(1→2)-β-D-methylglucuronopyranosyl-21-cinnamoyloxy-hederagenin and compound (3) was 3-O-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-2,19-dihydroxyepihederagenin-28-O-1-[26-(3-acetyl-4- methoxycinnamoyl-oxyhexa-cosanoyl)] glycerol. Literature survey indicates that compounds (2 and 3) are a new compounds separated from C. purpureum for the first time. Compound (2) showed molluscicidal activity at a concentration of 25ppm. © 2015, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.

Keywords

Cestrum purpureum; Chromatography; Glycerol; Hederagenin; Snails; Solanaceae; 3 o beta dextro glucopyranosyl alpha levo rhamnopyranosyl 2,19 dihydroxyepihederagenin 28 o 1 [26 (3 acetyl 4 methoxycinnamoyl oxyhexa cosanoyl)]glycerol; 3 o beta dextro glucopyranosyl beta dextro methylglucuronopyranosyl 21 cinnamoyloxy hederagenin; alkaloid; Cestrum purpureum extract; chemical compound; flavonoid; glycoside; plant extract; saponin derivative; sterol derivative; tannin derivative; unclassified drug; ursolic acid; Article; Biomphalaria alexandrina; carbon nuclear magnetic resonance; column chromatography; concentration response; drug activity; hydrolysis; infrared spectroscopy; mass spectrometry; molluscicidal activity; nonhuman; phytochemistry; plant leaf; proton nuclear magnetic resonance; silica gel column chromatography; structure activity relation; thin layer chromatography

Citation Information

Scopus Citations: 4

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