Diagnostic and prognostic significance of serum and tissue galectin 3 expression in patients with carcinoma of the bladder

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El Gendy H.; Madkour B.; Abdelaty S.; Essawy F.; Khattab D.; Hammam O.; Nour H.H.

Journal: Current Urology

Publisher: S. Karger AG

Publication Date: October 2014

Volume / Issue: Volume 7 / Issue 4

Pages: 185–190

ISSN: 16617649

DOI: 10.1159/000365673

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

El Gendy H., Department of Clinical and Chemical Pathology, Ain Shams University, Cairo, Egypt; Madkour B., Department of Clinical and Chemical Pathology, Egypt; Abdelaty S., Department of Clinical and Chemical Pathology, Egypt; Essawy F., Department of Clinical and Chemical Pathology, Egypt; Khattab D., Department of Clinical and Chemical Pathology, Ain Shams University, Cairo, Egypt; Hammam O., Department of Pathology, Theodor Bilharz Research Institute, Guiza, Egypt; Nour H.H., Department of Urology, Theodor Bilharz Research Institute, Guiza, Egypt

Abstract

Background: Galectins are group of proteins found in the cytoplasm, nucleus, cell surface and extracellular matrix. Galectin 3 (Gal-3) displays pathological expression in a variety of processes such as tumorigenesis.; Patients and Method: 70 patients classified into the control group, cystitis group, transitional cell carcinoma group, and squamous cell carcinoma group were enrolled in this study which aimed to detect the serum level and the intensity of tissue expression of Gal-3.; Results: Both serum level and tissue expression of Gal-3 were statistically higher in bladder cancer patients compared to the other groups. Gal-3 level expression increased from low to high grade urothelial tumors, with a statistically significant increase of its level and expression between muscle invasive and non-muscle invasive Ta urothelial tumors.; Conclusion: The serum Gal-3 level is sensitive and specific for the diagnosis of bladder cancer. The prognostic significance of tissue expression is to be confirmed. Copyright © 2013 S. Karger AG, Basel.

Keywords

Bladder cancer; Galectin 3; Schistosomiasis; Squamous cell carcinoma; Transitional cell carcinoma; adult; aged; Article; bladder carcinogenesis; bladder carcinoma; cancer diagnosis; cancer grading; cancer patient; cancer prognosis; controlled study; diagnostic test accuracy study; female; human; human tissue; major clinical study; male; protein blood level; protein expression; sensitivity and specificity; tissue level; tumor invasion

Citation Information

Scopus Citations: 20

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