Impact of anthropometric measures and serum leptin on severity of gastroesophageal reflux disease

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdelkader N.A.; Montasser I.F.; Bioumy E.E.; Saad W.E.

Journal: Diseases of the Esophagus

Publisher: John Wiley and Sons Inc.

Publication Date: 29 August 2014

Volume / Issue: Volume 28 / Issue 7

Pages: 691–698

ISSN: 11208694

DOI: 10.1111/dote.12271

Scopus: View on Scopus

PubMed: 25168182

Document Type: Article

Authors and Affiliations

Abdelkader N.A., Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Montasser I.F., Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Bioumy E.E., Department of Tropical Medicine, Theodor Bilharz Research Institute, Cairo, Egypt; Saad W.E., Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Abstract

The aim of this prospective study was to evaluate the impact of obesity, determined by different anthropometric measures, on clinical and endoscopic severity of GERD and the relation between serum leptin and clinical and endoscopic severity of GERD in Egyptian patients. The study was carried out at Ain Shams University Hospitals and Theodor Bilharz Research Institute, Cairo, Egypt. A total of 60 patients with clinically and endoscopically evident gastroesophageal reflux disease (GERD) were enrolled in this study as well as 20 healthy subjects matched for age and gender serving as the control group. Patients were divided according to their body mass index (BMI) into two groups: group 1 (n = 30): overweight and obese (BMI ≥25 and/or waist-to-height ratio [WHtR] ≥0.5) and group 2 (n = 30): normal weight (BMI ≥18 to <25 and/or WHtR ≥0.4 to <0.5). Upper gastrointestinal endoscopy, anthropometric measures, and symptom severity score questionnaire were done for all patients. Serum leptin hormone was assessed for patients and control groups.The evidence revealed statistically significant difference between the two groups in terms of different anthropometric measures (P < 0.00) except the height (P < 0.9), abdominal fat depot equations (P < 0.00), endoscopic findings according to Los Angeles classification (P < 0.001), symptom severity score (P < 0.00), and serum leptin hormone (43.96 ± 23.50 in group 1 vs. 7.5133 ± 8.18294 in group 2 and 6.98 ± 5.90 in the control group) (P = 0.00). Obesity in general and central (abdominal) obesity specifically has significant impact on clinical and endoscopic severity of GERD. Increased leptin hormone level is associated with clinical and endoscopic severity of GERD. Future trial on larger number of patients is emphasized. © 2015 International Society for Diseases of the Esophagus.

Keywords

Anthropometric measure; Gastroesophageal reflux disease; Leptin; Abdominal Fat; Adult; Anthropometry; Body Height; Body Mass Index; Case-Control Studies; Egypt; Endoscopy, Gastrointestinal; Female; Gastroesophageal Reflux; Healthy Volunteers; Humans; Male; Middle Aged; Obesity; Prospective Studies; Severity of Illness Index; abdominal obesity; aged; area under the curve; Article; body mass; controlled study; disease severity; Egyptian; gastrointestinal endoscopy; hip circumference; hormone blood level; human; intraabdominal fat; lipid storage; major clinical study; prediction; priority journal; prospective study; questionnaire; receiver operating characteristic; scoring system; sensitivity and specificity; subcutaneous fat; waist circumference; waist to height ratio; blood; case control study; complication; normal human; pathology

Citation Information

Scopus Citations: 17

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