Comparison between the effects of intraoperative human albumin and normal saline on early graft function in renal transplantation

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdallah E.; El-Shishtawy S.; Mosbah O.; Zeidan M.

Journal: International Urology and Nephrology

Publisher: Kluwer Academic Publishers

Publication Date: 24 July 2014

Volume / Issue: Volume 46 / Issue 11

Pages: 2221–2226

ISSN: 3011623

DOI: 10.1007/s11255-014-0785-z

Scopus: View on Scopus

PubMed: 25056504

Document Type: Article

Authors and Affiliations

Abdallah E., Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba Giza, 12411, Egypt; El-Shishtawy S., Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt; Mosbah O., Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt; Zeidan M., Department of Anesthesiology, Theodor Bilharz Research Institute, Cairo, Egypt

Abstract

Purpose: The aim of the current study was to compare the effects of intraoperative infusion of 20 % human albumin versus 0.9 % normal saline on early and late graft function in renal transplantation.; Methods: This prospective, randomized study was conducted on 44 patients with end-stage renal disease undergoing kidney transplantation. Patients were 32 males (72.7 %) and 12 females (27.3 %) with a mean age of 54.35 ± 11.15 years (range 20–58 years). Patients with cardiac disease and liver dysfunction were excluded from the study. Twenty-two of the 44 patients were given intraoperative intravenous infusion of 20 % human albumin with 0.9 % normal saline (albumin group), and the remaining 22 patients received intraoperative intravenous infusion of 0.9 % normal saline alone (saline group), as part of the intraoperative fluid hydration to keep central venous pressure between 10 and 15 mm of Hg.; Results: There was no statistically significant difference in mean intravenous fluid volume infused until the end of surgery between the saline group and the albumin group (P = 0.8326). Time of onset of diuresis and total intraoperative urine output were statistically insignificant between the two groups (P = 0.6255, P = 0.9231, respectively). Post-transplant serum creatinine on day 1, 3 and 5 between the albumin and saline groups were comparable (P = 0.8998, P = 0.7257, P = 0.8092, respectively). Post-transplant urine output on day 1, 3 and 5 between the albumin and saline groups were also comparable (P = 0.653, P = 0.9075, P = 0.946, respectively). Mean postoperative weight gain was higher in the saline group compared with the albumin group, but was not statistically significant (P = 0.6348).; Conclusions: This study revealed that the use of 20 % human albumin as an intraoperative volume expander provides no more benefit than the use of 0.9 % normal saline in terms of immediate graft function in living donor renal transplantation. © 2014, Springer Science+Business Media Dordrecht.

Keywords

CVP; Early graft function; Human albumin; Renal transplantation; Adult; Albumins; Central Venous Pressure; Female; Fluid Therapy; Graft Rejection; Graft Survival; Humans; Infusions, Intravenous; Intraoperative Care; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Prognosis; Prospective Studies; Sodium Chloride; Young Adult; creatinine; cyclosporin; furosemide; infusion fluid; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; prednisolone; Ringer lactate solution; albuminoid; Article; clinical article; controlled study; creatinine blood level; diuresis; drug infusion; end stage renal disease; human; hydration; immunosuppressive treatment; intraoperative period; kidney graft rejection; multicenter study; postoperative period; prospective study; randomized controlled trial; renal graft dysfunction; urine volume; weight gain; clinical trial; comparative study; intravenous drug administration; peroperative care; physiology; procedures

Citation Information

Scopus Citations: 14

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