Anti-C1q antibodies in lupus nephritis: Detection and relationship with disease activity

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Raafat M.; Nabil M.; AbouZeid S.; Hassanein A.S.

Journal: Life Science Journal

Publisher: Zhengzhou University

Publication Date: 2014

Volume / Issue: Volume 11 / Issue 12

Pages: 940–946

ISSN: 10978135

DOI: 10.7537/marslsj111214.163

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Raafat M., Nephrology Departments, Theodor Bilharz Research Institute, Cairo, Egypt; Nabil M., Nephrology Departments, Theodor Bilharz Research Institute, Cairo, Egypt; AbouZeid S., Nephrology Departments, Theodor Bilharz Research Institute, Cairo, Egypt; Hassanein A.S., Hematology Departments, Theodor Bilharz Research Institute, Cairo, Egypt, AL-Ghad International College for Applied Medical Sciences for Girls, Jeddah, Saudi Arabia

Abstract

Background: Systemic Lupus Erythromatosis (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations. Glomerulonephritis is one of the commonest and most serious manifestations of SLE. Several autoantibodies, especially those against double stranded DNA (anti-dsDNA), are believed to play a major role in the induction of glomerular inflammation. C1q is a multifunctional protein that binds to immune complexes deposited on tissues, including the kidney and aids in their solubilization and removal. C1q also plays a role in apoptotic cell debris removal. The binding of anti-C1q antibodies and other proteins to C1q is potentially of concern as it may impede the ability of C1q to carry out its normal anti-inflammatory functions such as immune complex clearance and removal of apoptotic debris. The aim of the present study: to evaluate the presence of anti- C1q antibodies in patients with SLE, with and without renal involvement, and to correlate their presence and levels with disease activity and occurrence of nephropathy. Method: Forty SLE patients were recruited in the study, they were divided in two groups according to their clinical status and laboratory investigations, group 1 was comprised 15 SLE patients without evidence of nephritis while Group 2 comprised 25 SLE patients who were diagnosed to have lupus nephritis. Sera were tested for anti C1q by ELISA technique. Result: A statistical significant difference between group 1 and 2 as regard anti- C1q (p = 0.002) was noticed. In those with lupus nephritis, anti-C1q was found to correlate significantly with other parameters assessing lupus activity such as ESR (p =0.017), creatinine clearance, (p =0.029), proteinuria (p =0.003), and Anti-dsDNA (p =0.014). Conclusion: Anti-Clq autoantibodies correlate with renal disease activity and with renal flare-ups like other standard parameters, such as proteinuria, complement levels anti-dsDNA. Anti-C1q antibodies can be considered as a reliable sensitive and specific biomarker to diagnose nephritis flare in patients with SLE. © 2014, Zhengzhou University. All rights reserved.

Keywords

Anti-dsDNA; C1q; SLE

Citation Information

Scopus Citations: 0

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