Therapeutic potential of natural products of plant origin and available synthetic derivatives in the treatment of schistosomiasis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Botros S.S.; Mohamed M.A.; Radwan A.M.

Journal: Studies in Natural Products Chemistry

Publisher: Elsevier B.V.

Publication Date: 2026

Volume / Issue: Volume 88

Pages: 333–370

ISSN: 15725995

DOI: 10.1016/B978-0-443-49146-7.00012-1

Scopus: View on Scopus

Document Type: Book chapter

Authors and Affiliations

Botros S.S., Pharmacology and Medicinal Chemistry Departments, Theodor Bilharz Research Institute, Giza, Egypt; Mohamed M.A., Pharmacology and Medicinal Chemistry Departments, Theodor Bilharz Research Institute, Giza, Egypt; Radwan A.M., Research Department, Academy of Scientific Research and Technology, Cairo, Egypt

Abstract

Schistosomal infections continue to pose a significant global health challenge, particularly in developing countries. Despite advances in modern medicine, reliance on the single drug praziquantel presents several hurdles. These include limited efficacy against juvenile worms, concerns about drug resistance, and the complexity of treating hybrid infections involving both human-specific and animal-specific schistosomes. These hybrid infections negatively impact elimination efforts due to increased fecundity, different pathogenesis and compatibility with snails, and are also known to cause more severe disease. Furthermore, synthetic drugs currently available are associated with adverse effects, underscoring the need for alternative antischistosomal therapies. Natural products, particularly those derived from plants, offer promise. This comprehensive chapter delves into the anthelmintic activity of plant-derived compounds, their mechanisms of action, and bioassay procedures for antischistosomal evaluation. Additionally, we explore relatively novel approaches, such as nano-drug delivery systems, to enhance the schistosomicidal potency of plant-based drug candidates. Our comprehensive chapter, spanning 1994-2025, focuses on identifying plants, plant extracts, and isolated compounds that demonstrate feasible and effective antischistosomal properties. Moreover, we investigate derivatives of these plants, which may serve as valuable structures for drug synthesis and optimisation, ultimately contributing to the development of new treatments for schistosomiasis. © 2026 Elsevier B.V.

Keywords

Essential oils; Nanotechnology; Schistosomiasis; Secondary metabolites; Snail

Citation Information

Scopus Citations: 0

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