Biological and chemical study of exopolysaccharides produced by marine microorganisms and its effect on arthritis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El Awady M.E.; Hamed A.A.; Selim M.S.; Selim H.M.R.M.; Gomaa F.A.M.; Moustafa N.M.; El-Wakil E.S.; Mohamed S.S.; Ghareeb M.A.

Journal: Marine Microbiome and Microbial Bioprospecting: Diversity and Bioactive Potential

Publisher: Elsevier

Publication Date: 2026

Pages: 581–614

DOI: 10.1016/B978-0-443-26771-0.00034-5

Scopus: View on Scopus

Document Type: Book chapter

Authors and Affiliations

El Awady M.E., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Hamed A.A., Microbial Chemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Selim M.S., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Selim H.M.R.M., Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia; Gomaa F.A.M., Pharamcognosy and Medicinal Herbs Department, Faculty of Pharmacy, Al-Baha University, AlBaha, Saudi Arabia, Microbiology and Immunology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt; Moustafa N.M., Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Basic Medical Science Department, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia; El-Wakil E.S., Department of Parasitology, Theodor Bilharz Research Institute, Giza, Egypt; Mohamed S.S., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Giza, Egypt

Abstract

Inflammatory diseases have emerged as a significant public health concern due to their substantial socioeconomic impact on people, family members, and the national healthcare system of the nation. Chronic inflammation triggered by rheumatoid arthritis is one of the most major causes of death worldwide. Similarly, inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease increase morbidity and mortality among patients due to severe gastroenteritis. The management of diabetes-related wounds is a significant challenge in the field of medicine, as it is accompanied with significant side effects. An exopolysaccharide (EPS) is a sugar polymer that is produced mainly by bacteria. The exopolysaccharides have strong biological roles. Several pharmacological benefits have been gained from the treatment with EPS besides absence of considerable side effects. The specific position of N-acetyl group seems to have an extra role in the antiarthritis effect of polysaccharides. EPS exhibits significant biological action as an antioxidant, antibacterial, antiviral, anticoagulant, and anticancer agent and demonstrates positive impacts on rheumatoid arthritis (RA). © 2026 Elsevier Inc. All rights reserved.

Keywords

Arthritis; Bioactivities; Exopolysaccharides; Marine; Microorganism; Bacteria; Bioactivity; Pathology; Polysaccharides; Health concerns; Healthcare systems; Inflammatory disease; Marine microorganism; Rheumatoid arthritis; Side effect; Socio-economic impacts; Diseases

Citation Information

Scopus Citations: 0

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