Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ghiniwa A.I.; Zahran M.K.; El-Rafie H.M.; Ayad E.G.; Abdel-Aziz M.S.; Mohamed T.S.

Journal: Egyptian Journal of Chemistry

Publisher: National Information and Documentation Centre

Publication Date: 1 September 2025

Volume / Issue: Volume 68 / Issue 9

Pages: 715–728

ISSN: 4492285

DOI: 10.21608/ejchem.2025.369657.11482

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Ghiniwa A.I., Forensic Laboratory, Ministry of Interior General Administration of Criminal Evidence Investigation, 417 Ramses, El-Abaseya El-Bahareya, El Weili, Cairo, Egypt; Zahran M.K., Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, 11795, Egypt; El-Rafie H.M., Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., P.O. 12622 (ID: 60014618), Dokki, Giza, Egypt; Ayad E.G., Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, 11795, Egypt; Abdel-Aziz M.S., Microbial Chemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Mohamed T.S., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El -Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt

Abstract

This study evaluates antimicrobial cotton fabrics functionalized with silver nanoparticles (AgNPs) biosynthesized using Cichorium intybus L. (chicory) leaf extract. The eco-friendly synthesis leveraged phytoconstituents as dual reducing and stabilizing agents. Characterization via UV-vis spectroscopy (λmax=400 nm) and TEM confirmed spherical AgNPs (4.5–10.9 nm), while SEM-EDX verified uniform coating on cotton. The AgNP-cotton demonstrated enhanced antimicrobial efficacy against Gram-positive Staphylococcus aureus (25 mm inhibition zone), Gram-negative Escherichia coli (23 mm), fungal Candida albicans (25 mm), and Aspergillus niger (21 mm), attributed to AgNP-induced membrane disruption and ROS generation. Phytochemical analysis identified flavonoids, phenolics, and alkaloids with high concentrations (128.17 mg RE/g flavonoids; 459.94 mg GAE/g phenolics). Antioxidant assays revealed strong radical scavenging (IC50: 9.21 µg/mL ABTS; 17.14 µg/mL DPPH). This sustainable integration of phytochemicals and nanotechnology presents eco-friendly antimicrobial textiles with potential for medical applications, such as wound dressings and hospital linens, offering alternatives to conventional treatments. ©2025 National Information and Documentation Centre (NIDOC)

Keywords

Antimicrobial textiles; Antioxidant activity; Cichorium intybus; Green synthesis; Silver nanoparticles; UPLC-QTOF MS

Citation Information

Scopus Citations: 1

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