Role of Calcitonin Peptide Precursor and C Reactive Protein in Excluding Associated Co-infection in Patients With Viral Pneumonia Admitted to ICU

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Omar A.; Alwaseef M.A.; Shaheen M.A.E.; Ewis A.M.; Youssef I.H.; Khedr M.A.E.; Elsawy A.G.S.; Said S.R.A.; Alhangor A.F.A.; Ali W.E.; Abdelsamad A.M.; Attia A.A.; Elsayed M.M.; Adawy Z.; Ahmed L.A.; Mahrose H.K.A.; Metwally M.M.M.; Elsayed B.A.M.; Newishy H.M.; Radwan E.E.E.; Abozeed A.A.; Ageel M.A.; Hussein N.R.; Mahmoud I.F.; Abdelmottaleb N.A.

Journal: Journal of Natural Science, Biology and Medicine

Publisher: Think Biotech Limited

Publication Date: 2025

Volume / Issue: Volume 16 / Issue 2

ISSN: 9769668

DOI: 10.5281/zenodo.15587435

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Omar A., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Alwaseef M.A., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Shaheen M.A.E., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Ewis A.M., Department of Chest Diseases, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Youssef I.H., Department of Chest Diseases, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Khedr M.A.E., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Elsawy A.G.S., Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Said S.R.A., Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; Alhangor A.F.A., Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Ali W.E., Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; Abdelsamad A.M., Department of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Attia A.A., Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; Elsayed M.M., Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Adawy Z., Department of Chest Diseases, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Ahmed L.A., Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; Mahrose H.K.A., Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt; Metwally M.M.M., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Elsayed B.A.M., Department of Chest Diseases, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Newishy H.M., Medical Microbiology and lmmunology Department, Faculty of Medicine, Al- Azhar University, Cairo, Egypt; Radwan E.E.E., Department of Clinical Pathology, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt; Abozeed A.A., Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Cairo, Egypt; Ageel M.A., Anesthesiology and Critical Care, Department of Surgery, Faculty of Medicine, Jazan University, Saudi Arabia; Hussein N.R., Department of Clinical Pathology, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt; Mahmoud I.F., Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Abdelmottaleb N.A., Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Bacterial infection and a non-infectious inflammatory response require a refined distinction for clinical reasoning to be effective. [Calcitonin Peptide Precursor - Procalcitonin (PCT)] and C-reactive protein (CRP) have received considerable attention as inflammatory markers; however, the extent of their competitive diagnostic value, especially in the presence or absence of co-infections, remains fully explored. Methods: This retrospective observational study took account of PCT and CRP levels in 100 patients, fifty of whom had co-infections. Data were processed through non-parametric tests, including the Wilcoxon Signed-Rank Test within groups and the Mann-Whitney U Test across groups. Results: The Wilcoxon Signed-Ranks Test confirmed substantial decreases in PCT and CRP levels post-infection (Z = -6.125, p = .000 and Z = -6.154, p = .000, respectively), signifying the scale of their change. The Mann-Whitney U Test also confirmed the relevance of the investigated biomarkers, as within the group of patients with active infection, both PCT and CRP were significantly raised (PCT: U = 22.000, p = .000; CRP: U = .000, p = .000). The strength of the association between the biomarkers was measured using Spearman’s correlation. Conclusion: Group comparisons demonstrated significant reductions in PCT and CRP from initial to follow-up measurements. A comparison between the groups showed that the co-infection group had significantly higher levels of both PCT and CRP. Weak statistically non-significant correlations were observed between PCT and CRP. PCT and CRP levels were significantly higher in co-infected patients, indicating that these markers may be useful in cognitively diagnosing and monitoring infections. Additional studies are necessary to formulate appropriate diagnostic frameworks. © 2025 Journal of Natural Science, Biology and Medicine.

Keywords

C Reactive Protein; Calcitonin Peptide Precursor; Coinfection in Patients; ICU; Procalcitonin; Viral Pneumonia

Citation Information

Scopus Citations: 0

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