Harnessing miRNAs: A Novel Approach to Diagnosis and Treatment of Tuberculosis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Doghish A.S.; Abulsoud A.I.; Nassar Y.A.; Nasr S.M.; Mohammed O.A.; Abdel-Reheim M.A.; Rizk N.I.; Lutfy R.H.; Abdel Mageed S.S.; Ismail M.A.; Abd-Elhalim H.M.; Awad F.A.; Fayez S.Z.; Elimam H.; Mansour R.M.

Journal: Journal of Biochemical and Molecular Toxicology

Publisher: John Wiley and Sons Inc

Publication Date: 12 January 2025

Volume / Issue: Volume 39 / Issue 1

Article No.: e70119

ISSN: 10956670

DOI: 10.1002/jbt.70119

Scopus: View on Scopus

PubMed: 39799557

Document Type: Review

Authors and Affiliations

Doghish A.S., Department of Biochemistry, Badr University in Cairo (BUC), Cairo, Badr City, Egypt, Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Nasr City, Egypt; Abulsoud A.I., Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt; Nassar Y.A., Department of Botany, Biotechnology and Its Application Program, Faculty of Science, Mansoura University, Mansoura, Egypt; Nasr S.M., Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Giza, Egypt, School of Biotechnology, Badr University in Cairo, Cairo, Badr City, Egypt; Mohammed O.A., Department of Pharmacology, College of Medicine, University of Bisha, Bisha, Saudi Arabia; Abdel-Reheim M.A., Department of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia; Rizk N.I., Department of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, Egypt; Lutfy R.H., School of Biotechnology, Badr University in Cairo, Cairo, Badr City, Egypt; Abdel Mageed S.S., Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Badr City, Egypt; Ismail M.A., Applied Biotechnology Program, Faculty of Science, Ain Shams University, Cairo, Egypt; Abd-Elhalim H.M., School of Biotechnology, Badr University in Cairo, Cairo, Badr City, Egypt, Agricultural Research Center, Agricultural Genetic Engineering Research Institute, Giza, Egypt; Awad F.A., School of Biotechnology, Badr University in Cairo, Cairo, Badr City, Egypt; Fayez S.Z., School of Biotechnology, Badr University in Cairo, Cairo, Badr City, Egypt; Elimam H., Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt; Mansour R.M., Zoology and Entomology Department, Faculty of Science, Helwan University, Helwan, Egypt, Molecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo (BUC), Cairo, Badr City, Egypt

Abstract

Mycobacterium tuberculosis (Mtb) complex, responsible for tuberculosis (TB) infection, continues to be a predominant global cause of mortality due to intricate host-pathogen interactions that affect disease progression. MicroRNAs (miRNAs), essential posttranscriptional regulators, have become pivotal modulators of these relationships. Recent findings indicate that miRNAs actively regulate immunological responses to Mtb complex by modulating autophagy, apoptosis, and immune cell activities. This has resulted in increased interest in miRNAs as prospective diagnostic indicators for TB, especially in differentiating active infection from latent or inactive stages. Variations in miRNA expression during Mtb infection indicate disease progression and offer insights into the immune response. Furthermore, miRNAs present potential as therapeutic targets in host-directed therapy (HDT) techniques for TB infection. This work examines the function of miRNAs in TB pathogenesis, with the objective of identifying particular miRNAs that regulate the immune response to the Mtb complex, evaluating their diagnostic value and exploring their therapeutic implications in host-directed therapy for TB infection. The objective is to enhance comprehension of how miRNAs can facilitate improved diagnosis and treatment of TB. © 2025 Wiley Periodicals LLC.

Keywords

diagnosis; epigenetics; miRNA; pathogenesis; signaling; tuberculosis; Animals; Host-Pathogen Interactions; Humans; MicroRNAs; Mycobacterium tuberculosis; microRNA; adult; apoptosis; autophagy (cellular); diagnostic value; drug therapy; female; host pathogen interaction; human; immune response; immunocompetent cell; nonhuman; review; signal transduction; animal; genetics; microbiology; therapy

Citation Information

Scopus Citations: 13

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