Adipokine (adiponectin-rs1501299) Gene Variant and Patient Characteristics in Relation to Metabolic-associated Fatty Liver Disease

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed A.A.; Hassanin S.; Mohamed A.A.; Zaafar D.; Mohamed R.; Hassan M.B.; Hassanin A.-S.A.; Alsayed Abouahmad E.; Sakr M.A.; Abd el salam S.M.; Abdelghafour R.A.M.; Muharram N.M.; Darwish M.K.; faried S.; Nasraldin K.; Hafez W.

Journal: Journal of Clinical and Experimental Hepatology

Publisher: Elsevier B.V.

Publication Date: September 2024

Volume / Issue: Volume 14 / Issue 5

Article No.: 101409

ISSN: 9736883

DOI: 10.1016/j.jceh.2024.101409

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Green Open Access

Authors and Affiliations

Mohamed A.A., Department of Biochemistry, National Hepatology and Tropical Medicine Research Institute, Cairo, GOTHI, Egypt; Hassanin S., Department of Biochemistry, Faculty of Pharmacy, Modern University for Technology and Information, Egypt; Mohamed A.A., Intensive Care Department, Theodor Bilharz Research Institute (TBRI), El-Nile St., Warrak El-Hader, Giza, Imbaba, Egypt; Zaafar D., Clinical Pharmacology Department, Faculty of Pharmacy, Modern University for Technology and Information, Egypt; Mohamed R., Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; Hassan M.B., Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; Hassanin A.-S.A., Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Minia University, Egypt; Alsayed Abouahmad E., Department of Clinical Pathology, Faculty of Medicine, Minia University, Egypt; Sakr M.A., Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez University, P.O. Box: 43221, Suez, Egypt; Abd el salam S.M., Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez University, P.O. Box: 43221, Suez, Egypt; Abdelghafour R.A.M., Department of Internal Medicine, Damanhur National Medical Institute, GOTHI, Egypt; Muharram N.M., Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt; Darwish M.K., Chemistry Department (Biochemistry Branch), Faculty of Science, Suez University, Suez, P.O. 43518, Egypt, College of Applied Medical Sciences, Shaqraa University, Al Quwayiyah, Saudi Arabia; faried S., Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute, Cairo, GOTHI, Egypt; Nasraldin K., Faculty of Biotechnology, Modern Science and Arts University, Egypt; Hafez W., Internal Medicine Department, Medical Research and Clinical Studies Institute, 33 El Buhouth St, Ad Doqi, Cairo Governorate, Dokki, 12622, Egypt

Abstract

Background: Several genetic and metabolic variables, most notably the variation in the adipokine gene rs1501298, have been linked to metabolic-associated fatty liver disease etiopathogenesis (MAFLD). Liver biopsy, the gold standard for diagnosing MAFLD, is an invasive procedure; therefore, alternative diagnostic methods are required. Consequently, the integration of these metabolic variables with some of the patients’ characteristics may facilitate the development of noninvasive diagnostic methods that aid in the early detection of MAFLD, identification of at-risk individuals and planning of management strategies. Methods: This study included 224 Egyptians (107 healthy individuals and 117 MAFLD patients). Age, sex, BMI, clinical and laboratory characteristics, and rs1501299 adipokine gene polymorphisms were examined. The rs1501299 variant, insulin resistance, hypertension, obesity, blood pressure, lipid profile, hemoglobin A1C level, and hepatic fibrosis predictors were evaluated for MAFLD risk. The feasibility and effectiveness of developing non-invasive MAFLD diagnostic models will be investigated. Results: The +276G/T (rs1501299) polymorphism (GG vs GT/TT) was linked with MAFLD (OR: 0.43, CI: 0.26–0.69, P = 0.002). The GG variants had lower MAFLD rates than those of the GT and TT variants. In addition to altered lipid profiles, patients with MAFLD showed increased gamma-glutamyl transferase levels (GGT: 56 IU/L vs. 36 IU/L). Genetic diversity also affects the accuracy of hepatic fibrosis and steatosis prediction. Hepatic fibrosis and steatosis predictors had receiver operating characteristic (ROC) AUCs of 0.529%, 0.846%, and 0.700–0.825%, respectively. We examined a diagnostic model based on these variables and demonstrated its effectiveness. Conclusion: The Adipokine variant rs1501299 increased the risk of MAFLD. Identifying and genotyping this variation and other metabolic variables allow for a noninvasive diagnostic model for early MAFLD diagnosis and identification of those at risk. This study illuminates the prevention and management of MAFLD. Further research with more participants is needed to verify these models and to prove their MAFLD diagnostic efficacy. © 2024 Indian National Association for Study of the Liver

Keywords

adipokine gene polymorphism; hepatic indices; metabolic metabolic-associated fatty liver disease; metabolic syndrome; adipocytokine; adiponectin; biological marker; gamma glutamyltransferase; hemoglobin A1c; lipid; adult; area under the curve; Article; blood pressure; body mass; case control study; clinical feature; controlled study; demographics; DNA polymorphism; echography; Egyptian; fatty liver; female; gene frequency; genetic variability; genetic variation; genotype; haplotype; human; hypertension; insulin resistance; laboratory test; liver fibrosis; major clinical study; male; metabolic fatty liver; obesity; predictive value; receiver operating characteristic; retrospective study; sensitivity and specificity; single nucleotide polymorphism; young adult

Citation Information

Scopus Citations: 1

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