Association of LDLR Gene Polymorphism with the Risk of Cardiovascular Disease in End-Stage Kidney Disease Patients on Maintenance Hemodialysis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Osman E.A.; Shawky H.; Abbas R.M.; Metwaly A.A.; Ibrahim A.H.; Khanany F.M.

Journal: Indian Journal of Nephrology

Publisher: Scientific Scholar LLC

Publication Date: 15 July 2024

Volume / Issue: Volume 35 / Issue 1

Pages: 29–33

ISSN: 9714065

DOI: 10.25259/IJN_33_2024

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Osman E.A., Department of Clinical Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Shawky H., Department of Clinical Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Abbas R.M., Department of Clinical Chemistry, Ain Shams University, Cairo, Egypt; Metwaly A.A., Department of Intensive Care, Theodor Bilharz Research Institute, Giza, Egypt; Ibrahim A.H., Department of Nephrology, Theodor Bilharz Research Institute, Giza, Egypt; Khanany F.M., Department of Clinical Chemistry, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Background: The low-density lipoprotein receptor (LDLR) is essential for regulating intracellular cholesterol levels. Mutations in the LDLR gene can cause a increase in LDL cholesterol levels in the blood, elevating the vulnerability to cardiovascular disease (CVD). This study evaluated the correlation between the LDLR rs688 polymorphism and CVD risk in chronic kidney disease (CKD). Materials and Methods: Polymorphism in this case-control study was genotyped using the TaqMan real-time polymerase chain reaction in a cohort of 100 CKD patients (Group I) and 100 healthy controls (Group II). We examined the LDLR rs688 allele and genotype distribution in 50 CKD cases with CVD and 50 cases without CVD. Results: There was a significantly greater frequency of CT variant of LDL SNP rs688 in Group I than in Group II (p = 0.006). CT and TT genotypes were significantly higher in CKD patients with CVD, with odds ratios (ORs) (95% CI) of 4.3 (1.6–11.8, p = 0.004) and 7.6 (2.3–24.8, p = 0.001), respectively. Conclusion: SNP rs688 C>T detection in the LDLR gene showed that CT and TT genotypes are associated with elevated CVD risk in CKD. © 2025 Indian Journal of Nephrology | Published by Scientific Scho.

Keywords

Cardiovascular disease; Chronic kidney disease; LDLR; Rs688; SNP; cholesterol; creatine; high density lipoprotein cholesterol; low density lipoprotein cholesterol; low density lipoprotein receptor; triacylglycerol; adult; Article; cardiovascular risk; case control study; controlled study; CT genotype; echocardiography; electrocardiogram; end stage renal disease; female; gene mutation; genetic polymorphism; genotype; hemodialysis; human; major clinical study; male; middle aged; real time polymerase chain reaction; single nucleotide polymorphism; TT genotype

Citation Information

Scopus Citations: 0

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