The association of p21, inhibin, and Tob-1 expression with the clinicopathological characteristics of benign and malignant colorectal lesions

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Moussa M.; Abdullah A.M.; Youssef M.M.; Elwi D.; Helal N.S.

Journal: Beni-Suef University Journal of Basic and Applied Sciences

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 11 February 2024

Volume / Issue: Volume 13 / Issue 1

Article No.: 14

ISSN: 23148535

DOI: 10.1186/s43088-024-00471-3

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Moussa M., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Giza, Imbaba, 12411, Egypt; Abdullah A.M., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Giza, Imbaba, 12411, Egypt; Youssef M.M., Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt; Elwi D., Department of Pathology, Faculty of Medicine, Cairo University, Giza, Egypt; Helal N.S., Department of Pathology, Theodor Bilharz Research Institute, El-Nile Street, Warrak El-Hadar, Giza, Imbaba, 12411, Egypt

Abstract

Background: Worldwide, colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer-related deaths. p21, inhibin, and Tob-1 are tumor suppressors that play a role in the development and progression of several cancers, however, their role in CRC is not well-established. This study aims to evaluate the expression of these proteins by immunohistochemistry and correlate their expression with the clinicopathological characteristics of CRCs and preneoplastic lesions [adenomas and ulcerative colitis] to study the potential for their use as targeted therapies. The study was performed on sections of 30 CRCs, 30 adenomas, 30 UC, 30 chronic colitis, and 20 controls. Results: p21 expression was lower in CRCs and adenomas compared to inflammatory lesions (chronic colitis and UC). High-grade CRCs, adenomas with high-grade dysplasia, and UC with dysplasia showed insignificantly lower expression compared to their counterparts. Inhibin expression was absent in CRCs; however, its expression was higher in chronic colitis than in UC and adenomas. Adenomas with high-grade dysplasia and UC with dysplasia showed insignificantly higher expression than their counterparts. Tob-1 expression increased significantly from chronic colitis to UC to adenomas to CRCs. High-grade CRCs, adenomas with high-grade dysplasia, and UC with dysplasia showed higher expression compared to their counterparts. Conclusions: Decreased p21 and increased inhibin and Tob-1 expressions are associated with the progression of adenomas and UC to more dysplastic lesions, then possibly to CRC. Despite being tumor suppressors, the studied proteins may potentially have tumor-promoting properties. They can be useful targets for therapeutic intervention. © The Author(s) 2024.

Keywords

Chronic colitis; Colon adenoma; Colon cancer; Inhibin; p21; Risk assessment; Tob-1; Ulcerative colitis

Citation Information

Scopus Citations: 0

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