Insights into bioactive microbial natural products and drug discovery

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamed A.; Ghareeb M.; Soliman N.; Bakchiche B.; Bardaweel S.

Journal: Egyptian Pharmaceutical Journal

Publisher: Wolters Kluwer Medknow Publications

Publication Date: 2 February 2024

Volume / Issue: Volume 23 / Issue 1

Pages: 1–15

ISSN: 16874315

DOI: 10.4103/epj.epj_129_23

Scopus: View on Scopus

Document Type: Review

Access: All Open Access; Hybrid Gold Open Access

Authors and Affiliations

Hamed A., Microbial Chemistry Department, National Research Centre, Egypt; Ghareeb M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar Imbaba (P.O. 30), Giza, 12411, Egypt; Soliman N., Dairy Science Department, National Research Centre, 33 El-Buhouth Street Dokki, Giza, Egypt; Bakchiche B., Laboratory of Biological and Agricultural Sciences, Amar Telidji University, Laghouat, Algeria; Bardaweel S., Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman, Jordan

Abstract

Recently, natural products have attracted much attention as a valuable source for the discovery of new and potential lead compounds with widely diverse biological activities. Among all-natural product sources, microorganisms emerged as a potential pipeline for new drug leads and new chemical entities with promising biomedical applications. Since the discovery of the first bioactive microbial product, penicillin, the exploitation of microorganisms has led to the production of a variety of natural products ranging from alcohol to antibiotics with multiple applications, including inhibition of infectious diseases such as (antifungal, antibacterial, and antiviral) and noninfectious diseases like obesity, some kinds of diarrhea, cancer, anemia, atopic dermatitis, and diabetes. In this review, we aim to highlight the current literature describing the bioactive microbial natural products, produced by bacteria, fungi, and algae, which have distinct chemical structures that may serve as a robust platform for drug discovery inspiration. © 2024 Dental Research Journal.

Keywords

algae; Bacillus subtilis; fungus sp; microbial sources; secondary metabolites; Streptomyces sp; microbial products not classified elsewhere; natural product; alga; antimicrobial activity; biological activity; chemical structure; drug development; fungus; nonhuman; Review; Streptomyces

Citation Information

Scopus Citations: 10

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