Assessment of Urinary 8-Hydroxy-2-Deoxyguanosine as Oxidative DNA Damage for Diabetic Nephropathy

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Zaki M.; Reyad H.; Orban H.; Shahba M.A.; Wafy W.; Esmail M.M.; Girgiss M.W.; Youness E.

Journal: Egyptian Journal of Chemistry

Publisher: National Information and Documentation Centre

Publication Date: 5 February 2024

Volume / Issue: Volume 67 / Issue 6

Pages: 405–408

ISSN: 4492285

DOI: 10.21608/EJCHEM.2024.256342.8999

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Zaki M., Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt; Reyad H., Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt; Orban H., Department Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt; Shahba M.A., Department Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt; Wafy W., Department of Public Health, Theodor Bilharz Research Institute, Egypt; Esmail M.M., Department of Internal Medicine, Faculty of Medicine, Al-Azher University (for girls), Egypt; Girgiss M.W., Medical Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt; Youness E., Department Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre Cairo, Egypt

Abstract

Diabetic nephropathy (DN) is the main cause of chronic kidney disease (CKD), and represents the most common and serious complication of diabetes. 8-hydroxy-2′-deoxyguanosine (8-OHdG) emerged as a marker of DNA damage. Therefore, the study assessed association between urinary 8-OHdG and DN as early biomarker for DN. The study group included 100 volunteers, 50 cases with DN and 50 healthy control subjects matched in age with cases. The glycated hemoglobin (HbA1c), high sensitive C reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), 25 OH vitD3 and urinary 8-OHdG levels were measured. Anthropometric measures comprised body weight, height, waist circumference (WC) was measured. Significant increase in levels of HbA1c, urinary 8-OHdG, BMI and WC in DN group compared to control. Significant positive linear relation was observed between WC and urinary 8-OHdG. Moreover, significant decline of vitamin D3 and significant increase of ESR and CRP was observed in DN cases. Oxidative damage had a role in the development of DN and increased levels of 8-Hydroxy-2-Deoxyguanosine is independently associated with WC. Our study found that, both ESR and hs-CRP were increased in DN that may be independent risk factors correlated with the severity of disease. ©2024 National Information and Documentation Center (NIDOC)

Keywords

CRP; Diabetic nephropathy; ESR; HbA1c; urinary 8-OHdG

Citation Information

Scopus Citations: 1

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