Saccharomyces cerevisiae Bioactive Metabolites: Characterization and Biological Activities

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hathout A.S.; Ghareeb M.A.; Abdel-Nasser A.; Abu-Sree Y.

Journal: ChemistrySelect

Publisher: John Wiley and Sons Inc

Publication Date: 2024

Volume / Issue: Volume 9 / Issue 11

Article No.: e202304878

ISSN: 23656549

DOI: 10.1002/slct.202304878

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Hathout A.S., Food Toxicology and Contaminants, National Research Centre, 33 El-Buhouth St., Dokki, Cairo, 12622, Egypt; Ghareeb M.A., Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile St., Warrak El-Hadder, PO BOX 30, Imbaba, Giza, 12411, Egypt; Abdel-Nasser A., Food Toxicology and Contaminants, National Research Centre, 33 El-Buhouth St., Dokki, Cairo, 12622, Egypt; Abu-Sree Y., Food Toxicology and Contaminants, National Research Centre, 33 El-Buhouth St., Dokki, Cairo, 12622, Egypt

Abstract

This study aimed to extract bioactive secondary metabolites, determine volatile organic compounds, and polyphenols using GC/MS and LC/MS, and assess their total phenolic content, antimicrobial, antioxidant, and cytotoxic properties. The chemical analysis of S. cerevisiae NRLL Y-12633 ethyl acetate extract revealed eight volatile organic components, whereas the main component was phenyl ethyl alcohol (77.39 %). On the other hand, nineteen volatile organic compounds were identified in the ethyl acetate extract of S. cerevisiae NRRL Y-1089, whereas the most critical component was 2, 3-butanediol (60.74 %). The most abundant phenolic acids were syringic acid (25476.46 ng/mL), and cinnamic acid (5163.76 ng/mL) in the ethyl acetate extracts of S. cerevisiae NRLL Y-12633 and S. cerevisiae NRRL Y-1089 respectively. Flavonoid, naringenin, was also found in the ethyl acetate extract of S. cerevisiae NRLL Y-12633, whereas daidzein and rutin were detected in the ethyl acetate extract of S. cerevisiae NRRL Y-1089. The total phenolic content of S. cerevisiae NRRL Y-12633 ethyl acetate extract was found to be greater than that of S. cerevisiae NRRL Y-1089 ethyl acetate extract. Data revealed that S. cerevisiae ethyl acetate extracts displayed antioxidant and antimicrobial activity, whereas only the ethyl acetate extract of S. cerevisiae NRRL Y-1089 showed anticancer activity. © 2024 Wiley-VCH GmbH.

Keywords

antioxidant activity; cytotoxic activity; polyphenols; Saccharomyces cerevisiae; volatile organic compounds

Citation Information

Scopus Citations: 5

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