Role of Indocyanine Green in Diagnostic Staging Laparoscopy in Intra-Abdominal Malignancy

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Badreldeen M.H.S.; Omar A.F.; Hegazy T.O.; Esmat M.E.; Essawy M.M.; Hedaya M.S.; El Sayed L.R.; Rady M.M.; Abdo M.

Journal: Surgery, Gastroenterology and Oncology

Publisher: Editura Celsius

Publication Date: 2024

Volume / Issue: Volume 29 / Issue 2

Pages: 121–130

ISSN: 2559723X

DOI: 10.21614/sgo-677

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Badreldeen M.H.S., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt; Omar A.F., Department of General Surgery, Faculty of Medicine, Cairo University, Egypt; Hegazy T.O., Department of General Surgery, Faculty of Medicine, Cairo University, Egypt; Esmat M.E., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt; Essawy M.M., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt; Hedaya M.S., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt; El Sayed L.R., Department of Radiology, Theodor Bilhariz Research Institute, Cairo, Egypt; Rady M.M., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt; Abdo M., Department of General Surgery, Theodor Bilharz Research Institute, Cairo, Egypt

Abstract

Background: Patients with abdominal cancers may present with advanced disease either locally or metastatic and so, accurate staging help in selection of the appropriate treatment plan (curative or palliative). Up to 50% of patients diagnosed with colorectal cancers (CRC) and 40% of patients diagnosed with pancreatic cancers will have metastatic hepatic lesions during the course of the disease, where 7% of patents with CRC and 14% of patients with advanced gastric cancers will develop peritoneal metastases. Despite advances in preoperative imaging used for diagnosis and staging as CT, MRI and PET-CT many patients are diagnosed either intra-operative or in early post-operative period with distant metastases. Aim of the work: The study aim is to assess and provide precise data for the efficacy and added value of using Indocyanine Green (ICG) in diagnostic staging laparoscopy in intra-abdominal malignancy, especially in the identification of hepatic malignancies or liver and peritoneal metastases. Patients and Methods: This is a cross-sectional prospective study which was conducted on thirty patients with operable intra-abdominal malignancy presented to Theodor Bilhariz research institute from February 2022 to July 2023. Results: In our study, total number was 12 hepatic lesions, 8 lesions were discovered during routine pre-operative investigation and 11 lesions were identified by intra-operative ICG florescence with histopathological confirmation of metastasis in 57%. Conclusion: ICG is a safe and applicable tool for intra-operative assessment and detection of liver lesions with high sensitivity. It is not specific for malignant lesions rather than hypervascular lesions, affecting its specificity. Another study with larger sample size and dedicated post-operative follow up may be needed for more precise data. © Celsius Publishing House.

Keywords

florescence maging; indocyanine green; intra-abdominal malignancy; liver metastasis; near infra-red; peritoneal carcinomatosis; staging laparoscopy

Citation Information

Scopus Citations: 0

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