Oxidative stress, histopathological and genotoxicity of copper oxide nanoparticles in Biomphalaria alexandrina snail

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Fol M.F.; Abdel-Ghaffar F.A.; Hassan H.A.-M.; Ibrahim A.M.

Journal: Scientific Reports

Publisher: Nature Research

Publication Date: 2024

Volume / Issue: Volume 14 / Issue 1

Article No.: 25187

ISSN: 20452322

DOI: 10.1038/s41598-024-74439-9

Scopus: View on Scopus

PubMed: 39448690

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Fol M.F., Zoology Department, Faculty of Science, Cairo University, Giza, Egypt; Abdel-Ghaffar F.A., Zoology Department, Faculty of Science, Cairo University, Giza, Egypt; Hassan H.A.-M., Zoology Department, Faculty of Science, Cairo University, Giza, Egypt; Ibrahim A.M., Environmental Research & amp; Medical Malacology Department, Theodor Bilharz Research Institute (TBRI), Giza, Egypt

Abstract

Higher usage of copper oxide nanomaterials in industrial and biomedical fields may cause an increase of these nanoparticles in aquatic environments, which could have a detrimental ecological effect. Thus, the objective of this study was to evaluate the acute toxicity of copper oxide nanoparticles on the freshwater gastropod, Biomphalaria alexandrina. Transmission electron microscopy, x-ray diffraction analysis and UV–VIS spectrophotometer of CuO NPs revealed a typical TEM image and a single crystal structure with average crystallite size of approximately 40 nm also, a sharp absorption band was appeared. Following exposure to sub-lethal concentrations of CuO NPs (LC10, 15.6 mg/l and LC25, 27.2 mg/l), treated snails revealed a significant decrease (p < 0.05) in total antioxidant capacity, reduced glutathione contents as well as catalase, and sodium dismutase activities were significantly declined (p < 0.05) in comparison to the control group. Also, histopathological alterations were observed in the digestive gland, including ruptured and vacuolated digestive cells, and a marked increase in the number of secretory cells and the severity of the damage increased with rising concentrations. Furthermore, changes in RAPD profiles were detected in the treated snails. In conclusion, our research highlights the potential ecological impact of CuO NPs release in aquatic ecosystems and advocates for improved monitoring and regulation of CuO NPs industrial usage and disposal. © The Author(s) 2024.

Keywords

Biomphalaria alexandrina; CuO NPs; Histopathology; RAPD; Animals; Antioxidants; Biomphalaria; Catalase; Copper; DNA Damage; Glutathione; Metal Nanoparticles; Oxidative Stress; Water Pollutants, Chemical; X-Ray Diffraction; antioxidant; cupric oxide; cuprous oxide; metal nanoparticle; animal; chemistry; drug effect; metabolism; toxicity; water pollutant; X ray diffraction

Citation Information

Scopus Citations: 9

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