Mineral contents, Antioxidant and Antimicrobial Activities of Algerian Terfezia claveryi extracts

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Guenane H.; Bakchiche B.; Erenler R.; Yildiz I.; Mohamed A.S.; El-Shazly M.A.M.

Journal: Fabad Journal of Pharmaceutical Sciences

Publisher: Society of Pharmaceutical Sciences of Ankara (FABAD)

Publication Date: 16 October 2023

Volume / Issue: Volume 49 / Issue 1

Pages: 19–36

ISSN: 13004182

DOI: 10.55262/fabadeczacilik.1326710

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Green Open Access

Authors and Affiliations

Guenane H., Laboratory of Biological and Agricultural Sciences (LBAS), Amar Telidji University, Laghouat, 03000, Algeria; Bakchiche B., Laboratory of Biological and Agricultural Sciences (LBAS), Amar Telidji University, Laghouat, 03000, Algeria; Erenler R., Department of Chemistry, Faculty of Arts and Sciences, Tokat, Gaziosmanpasa University, Tokat, 60240, Turkey; Yildiz I., Department of Chemistry, Faculty of Arts and Sciences, Tokat, Gaziosmanpasa University, Tokat, 60240, Turkey; Mohamed A.S., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt; El-Shazly M.A.M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt

Abstract

Terfezia species are known for their high nutritional value and diverse biological activities due to their unique chemical composition. The current study aims to evaluate the different extracts of Terfezia claveryi Chatin for their in vitro antioxidant, antibacterial, total phenolic content, total flavonoid content and mineral content. The antioxidant activity was evaluated via 1,1-diphenyl-2-picrylhydrazyl (DPPH), ABTS and phosphomolybdenum assays. While the in vitro antibacterial activity was evaluated via disc diffusion method against Staphylococcus aureusas a Gram-positive bacteria as well as Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria. The total phenolic content (TPC) and total flavonoid content (TFC) were evaluated via Folin-Ciocalteu's and AlCl3 assays, respectively. The mineral content was evaluated via using atomic absorption spectrophotometer. In the antioxidant assays, the aqueous extract showed the most potent activity IC50/DPPH equal to 0.09mg/mL, IC50/ABTS equal to 0.24mg/mL and total antioxidant capacity equal to 0.10. Among all the tested extracts, the aqueous extract showed the highest TPC (176.67 mg GAE / g DW) and the highest TFC (14.53 mg ER / g DW). Obviously, the antioxidant activities are exist in a positive correlation with the TPC and TFC. On the other side, the tested extracts exhibited strong to moderate antibacterial activity against tested pathogenic microbial strains. The methanolic and aqueous extracts showed the most potent antibacterial activity against Pseudomonas aeruginosa with inhibition zones 21.91 and 15.79 mm, respectively. The extracts contain macroelements like Na (3293.01 mg kg-1dw) and K (21092.19 mg kg-1dw). Additionally, they contain micro-elements like Fe (16.45 mg kg-1dw), Cu (22.80 mg kg-1dw) and Ni (27.88 mg kg-1dw). LC/ESI-MS-MS was used to determine the chemical profile of the extract obtained from Terfezia claveryi. A total of seven phenolic compounds were selected. Rutin and hesperidin were primary compounds in the extract with 38.0089 and 22.4629 mg/g. In conclusion, T. claveryi extracts are considered promising sources of naturally occurring antioxidant and antimicrobial agents as well as their high nutritional values. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.

Keywords

Antimicrobial; Antioxidant; Mineral content; Terfezia claveryi; TFC; TPC; antiinfective agent; cuprous ion; iron; mineral; nickel; plant extract; potassium ion; sodium; Terfezia claveryi extract; unclassified drug; ABTS radical scavenging assay; antimicrobial activity; antioxidant activity; Article; assay; atomic absorption; chemical composition; disk diffusion; DPPH radical scavenging assay; electrospray mass spectrometry; Escherichia coli; Gram positive bacterium; IC50; in vitro study; nonhuman; nutritional value; phosphomolybdenum assay; Pseudomonas aeruginosa; total antioxidant capacity; zone of inhibition

Citation Information

Scopus Citations: 12

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