Bisphenol A effects on the host Biomphalaria alexandrina and its parasite Schistosoma mansoni

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Habib M.R.; Mohamed A.H.; Nassar A.H.A.; Sheir S.K.

Journal: Environmental Science and Pollution Research

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 19 August 2023

Volume / Issue: Volume 30 / Issue 43

Pages: 97824–97841

ISSN: 9441344

DOI: 10.1007/s11356-023-29167-4

Scopus: View on Scopus

PubMed: 37597145

Document Type: Article

Authors and Affiliations

Habib M.R., Medical Malacology Department, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Mohamed A.H., Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt; Nassar A.H.A., Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt; Sheir S.K., Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Abstract

Abstract: Bisphenol A (BPA) is one of the most potent endocrine-disrupting chemicals (EDCs) that adversely affect aquatic organisms. The present investigation explored the effects of exposure to BPA at 0.1 and 1 mgL−1 concentrations on the fecundity of Biomphalaria alexandrina, snail's infection with Schistosoma mansoni, and histology of the ovotestis and topographical structure of S. mansoni cercariae emerged from exposed snails. The 24 h LC50 and LC90 values of BPA against B. alexandrina were 8.31 and 10.88 mgL−1 BPA, respectively. The exposure of snails to 0.1 or 1 mgL−1 BPA did not affect the snail's survival. However, these concentrations caused an increase in the reproductive rate (Ro) of infected snails. A slight decrease in egg production was observed in snails exposed to 0.1 mgL−1 BPA after being infected (infected then exposed). However, a significant increase in egg production was noted in snails exposed to 1 mgL−1 BPA after infection with S. mansoni. Histopathological investigations indicated a clear alteration in the ovotestis tissue structure of exposed and infected-exposed groups compared to the control snails. Chronic exposure to BPA caused pathological alterations in the gametogenic cells. SEM preparations of S. mansoni cercariae emerged from infected-exposed snails showed obvious body malformations. From a public health perspective, BPA pollution may negatively impact schistosomiasis transmission, as indicated by the disturbance in cercarial production and morphology. However, it has adverse effects on the reproduction and architecture of reproductive organs of exposed snails, indicating that B. alexandrina snails are sensitive to sublethal BPA exposure. Graphical abstract: [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

Bisphenol A, Biomphalaria alexandrina, host-parasite interaction; Histopathology; Reproduction; Toxicity; Animals; Benzhydryl Compounds; Biomphalaria; Parasites; Schistosoma mansoni; 4,4' isopropylidenediphenol; benzhydryl derivative; disease transmission; egg production; fecundity; host-parasite interaction; public health; schistosomiasis; animal; parasite

Citation Information

Scopus Citations: 2

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