Oral microbiota and liver diseases

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Elghannam M.T.; Hassanien M.H.; Ameen Y.A.; Turky E.A.; Elattar G.M.; ElRay A.A.; Eltalkawy M.D.

Journal: Clinical Nutrition ESPEN

Publisher: Elsevier Ltd

Publication Date: April 2023

Volume / Issue: Volume 54

Pages: 68–72

ISSN: 24054577

DOI: 10.1016/j.clnesp.2022.12.030

Scopus: View on Scopus

PubMed: 36963900

Document Type: Review

Authors and Affiliations

Elghannam M.T., TBRI, Warak ALHadar, P.O. Box 30 Imbaba, Cairo, Egypt, Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hassanien M.H., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Ameen Y.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Turky E.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Elattar G.M., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; ElRay A.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Eltalkawy M.D., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Gut microbiota plays a crucial role in our health and particularly liver diseases, including NAFLD, cirrhosis, and HCC. Oral microbiome and its role in health and disease represent an active field of research. Several lines of evidence have suggested that oral microbiota dysbiosis represents a major factor contributing to the occurrence and progression of many liver diseases. The human microbiome is valuable to the diagnosis of cancer and provides a novel strategy for targeted therapy of HCC. The most studied liver disease in relation to oral–gut–liver axis dysbiosis includes MAFLD; however, other diseases include Precancerous liver disease as viral liver diseases, liver cirrhosis, AIH and liver carcinoma (HCC). It seems that restoring populations of beneficial organisms and correcting dysbiosis appears to improve outcomes in liver disorders. We discuss the possible role of oral microbiota in these diseases. © 2023 European Society for Clinical Nutrition and Metabolism

Keywords

AIH; HCC; Oral microbiota; Oral-gut-liver axis dysbiosis; Viral liver diseases; Carcinoma, Hepatocellular; Dysbiosis; Humans; Liver Cirrhosis; Liver Neoplasms; Microbiota; gamma interferon; granulocyte colony stimulating factor; interleukin 12p70; interleukin 17; interleukin 1beta; interleukin 4; interleukin 6; interleukin 7; interleukin 8; lipopolysaccharide; probiotic agent; tumor necrosis factor; autoimmune hepatitis; bacterial colonization; chronic viral hepatitis; disease exacerbation; fecal microbiota transplantation; human; intestine flora; liver cell carcinoma; liver disease; metabolic syndrome X; mouth flora; nonalcoholic fatty liver; oral gut liver axis dysbiosis; precancer; Prevotella; Review; Veillonella; liver tumor; microflora

Citation Information

Scopus Citations: 19

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