Phages for treatment of Staphylococcus aureus infection

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Samir S.

Journal: Progress in Molecular Biology and Translational Science

Publisher: Elsevier B.V.

Publication Date: 2023

Volume / Issue: Volume 200

Pages: 275–302

ISSN: 18771173

DOI: 10.1016/bs.pmbts.2023.03.027

Scopus: View on Scopus

PubMed: 37739558

Document Type: Book chapter

Authors and Affiliations

Samir S., Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Combating multi-drug resistant bacterial infections should be a universal urgency. The gram- positive Staphylococcus aureus (S. aureus) bacteria are generally harmless; healthy people frequently have them on their skin and nose. These bacteria, for the most part, produce no difficulties or only minor skin diseases. Antibiotics and cleansing of the affected region are usually the treatments of choice. S. aureus can become virulent causing serious infections that may lead to pustules to sepsis or death. Normally, it is thought that antibiotics may solve problems concerning bacterial infection; but unfortunately, Staphylococci have evolved mechanisms to resist drugs. Methicillin-Resistant Staphylococcus aureus (MRSA); both in hospitals and in the community, infections are evolving into dangerous pathogens. Health care practitioners may need to use antibiotics with more adverse effects to treat antibiotic-resistant S. aureus infections. Amid existing efforts to resolve this problem, phage therapy proposes a hopeful alternate to face Staphylococcal infections. When the majority of antibiotics have failed to treat infections caused by multidrug-resistant bacteria, such as methicillin- and vancomycin-resistant S. aureus, phage therapy may be an option. Here, we appraise the potential efficacy, current knowledge on bacteriophages for S. aureus, experimental research and information on their clinical application, and limitations of phage therapy for S. aureus infections. © 2023

Keywords

animal models; bacteriophages; Drug resistance; host range; phage cocktails; phage genome; Staphylococcus aureus; Anti-Bacterial Agents; Humans; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; antiinfective agent; antibiotic therapy; bacterial genome; bacteriophage; bacteriophage ab sa01; bacteriophage aptc c sa01; bacteriophage k; bacteriophage phb22a; bacteriophage phb25a; bacteriophage phb38a; bacteriophage phb40a; bacteriophage v1sa19; bacteriophage v1sa20; bacteriophage v1sa22; bacterium culture; bacterium identification; bone infection; cardiovascular infection; clinical trial (topic); drug efficacy; drug safety; experimental study; genetic engineering; genomics; human; infectious arthritis; invertebrate model; lung infection; Microvirus; mouse model; Myoviridae; nonhuman; phage jd219; phage therapy; plankton; Podoviridae; rabbit model; respiratory tract infection; Siphoviridae; skin infection; soft tissue infection; Staphylococcus aureus infection; methicillin resistant Staphylococcus aureus; Staphylococcus infection

Citation Information

Scopus Citations: 5

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