Estimation of Certain Biochemical and Immune System Responses in Mice with Schistosoma mansoni Infection and Treated with Mefloquine, Praziquantel and Chitosan Nanoparticles

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El-Qabbany M.M.; Metwally K.M.; Aly I.R.; Mahmoud S.; El-Menyawy H.M.; Sadek A.-S.M.

Journal: International Journal of Veterinary Science

Publisher: Unique Scientific Publishers

Publication Date: 2023

Volume / Issue: Volume 13 / Issue 1

Pages: 51–57

ISSN: 23043075

DOI: 10.47278/journal.ijvs/2023.064

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

El-Qabbany M.M., Zoology and Entomology Department, Faculty of Science, Al-Azhar University (Girls Branch), P. O. 11765, Cairo, 11865, Egypt; Metwally K.M., Zoology and Entomology Department, Faculty of Science, Al-Azhar University (Girls Branch), P. O. 11765, Cairo, 11865, Egypt; Aly I.R., Parasitology Department, Theodor Bilharz Research Institute, Giza, Egypt; Mahmoud S., Parasitology Department, Theodor Bilharz Research Institute, Giza, Egypt; El-Menyawy H.M., Zoology and Entomology Department, Faculty of Science, Al-Azhar University (Girls Branch), P. O. 11765, Cairo, 11865, Egypt; Sadek A.-S.M., Zoology and Entomology Department, Faculty of Science, Al-Azhar University (Girls Branch), P. O. 11765, Cairo, 11865, Egypt

Abstract

The current investigation was conducted to assess the potential impact of chitosan nanoparticles (CS-NPs) with the antimalarial mefloquine (Mef) and the anti-schistosomal praziquantel (PZQ) on some biochemical and immunological responses induced in mice infected with Schistosoma mansoni by measuring AST, ALT, ALP enzymes, TP, and IL-10. One hundred and twelve mice were grouped into fourteen separated collections with eight mice in each group. G1 (uninfected controls) and G2 (positive untreated control). At the 7th day post infection (PI), the groups were divided into the following groups: G3 (Mef dosage 400mg/kg), G4 (500mg/kg of CS-NPs), G5 (400mg/kg Mef with 500mg/kg CS-NPs), G6 (500mg/kg PZQ with 200mg/kg Mef), and G7 (500mg/kg CS-NPs accompanied with 200mg/kg Mef and 500mg/kg PZQ). At the 21st day PI, the groups from G8-G12 were treated with the same previous doses respectively. At the 35th day PI, the groups were as follows: G13 (a PZQ dosage of 1000mg/kg), and G14 (1000mg/kg PZQ with 500mg/kg CS-NPs). All the animals were sacrificed on the 56th day PI. Treatment with Mef accompanied with PZQ and CS-NPs at 7-and 21-days PI markedly reduced AST and ALT more than the other treated groups in comparison to the untreated positive mice. Accompanying Mef, PZQ and CS-NPs showed a synergistic effect on immunological response in schistosomiasis treatment as expressed in elevated levels of IL-10 when compared with uninfected control group. This represents an aid in improving the usage of drugs against schistosomiasis. © 2024, Unique Scientific Publishers. All rights reserved.

Keywords

Mefloquine; Nanoparticle; Praziquantel; S. mansoni

Citation Information

Scopus Citations: 7

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