Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Basyouni W.M.; Abbas S.Y.; El-Bayouki K.A.M.; El-Kady M.Y.; Abdelazeem N.M.; Dawood R.M.; Shemis M.A.

Journal: Egyptian Journal of Chemistry

Publisher: National Information and Documentation Centre

Publication Date: 2 January 2023

Volume / Issue: Volume 66 / Issue 9

Pages: 237–243

ISSN: 4492285

DOI: 10.21608/EJCHEM.2023.173878.7209

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Basyouni W.M., Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; Abbas S.Y., Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; El-Bayouki K.A.M., Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; El-Kady M.Y., Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt; Abdelazeem N.M., Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt; Dawood R.M., Microbial Biotechnology Department, National Research Center, Dokki, Cairo, Egypt; Shemis M.A., Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Cairo, Egypt

Abstract

Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high yields and purity with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells). ©2019 National Information and Documentation Center (NIDOC)

Keywords

Benzo[45]imidazo[1,2-a]pyrimidine; breast carcinoma; Cytotoxicity; Hepatocellular carcinoma; human cancer cell lines

Citation Information

Scopus Citations: 4

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