Chemical constituents of Ailanthus altissima (Mill.) swingle leaves growing in Egypt and their antioxidant activity

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed H.R.; El-Wakil E.A.; El-Hashash M.M.; Abdel-Hameed E.-S.S.

Journal: Acta Pharmaceutica Sciencia

Publisher: Istanbul Medipol University

Publication Date: 2023

Volume / Issue: Volume 61 / Issue 3

Pages: 213–233

ISSN: 13072080

DOI: 10.23893/1307-2080.APS6115

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Mohamed H.R., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; El-Wakil E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; El-Hashash M.M., Department of Chemistry, Faculty of Science, Ain-Shams University, El-Khalifa El-Mamoun, Abasia, Cairo, 11566, Egypt; Abdel-Hameed E.-S.S., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt

Abstract

Ailanthus altissima Swingle (Simaroubaceae), the tree of heaven, is characterized by its vast pharmacological potential beside its rich and diverse phytochemical pro-file. The plant leaves dry powder was extracted with 85% aqueous methanol and the crude extract was then fractionated in sequence with petroleum ether, methyl-ene chloride, ethyl acetate and n-butanol. The bioactive phytochemicals were sepa-rated from the ethyl acetate and the n-butanol fractions through column chroma-tography (CC) and quantified through HPLC-DAD. The chemical structure of the isolated pure compounds was identified through UV-Vis,1H-NMR,13C-NMR and TLC-MS spectroscopic analyses. The antioxidant activity of the pure compounds was estimated through their scavenging potential of DPPH•. Nine compounds were isolated and structurally elucidated as corilagin, astragalin, ellagic acid, gallic acid, isoquercetin, cynaroside, tellimoside, quercetin and luteolin. Ellagic acid, gallic acid and corilagin exhibited potent antioxidant activity. Corilagin derived from A. altissima can serve as potent natural antioxidant alternative. © 2023, Istanbul Medipol University. All rights reserved.

Keywords

Ailanthus altissima; antioxidant; corilagin; HPLC-DAD; phenolics; butanol; ellagic acid; flavonoid; gallic acid; isoquercetin; luteolin; luteolin 7 glucoside; phenol derivative; phytochemical; plant extract; quercetin; Ailanthus; Ailanthus altissimus; antioxidant activity; Article; chemical structure; chromatography; column chromatography; cyclization; DPPH radical scavenging assay; dry powder; electrospray mass spectrometry; glycosylation; high performance liquid chromatography; medicinal plant; nonhuman; nuclear magnetic resonance spectroscopy; oxidative stress; paper chromatography; plant leaf; plant root; plant taxonomy; thin layer chromatography

Citation Information

Scopus Citations: 3

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