The Activity of Gamma Irradiated Poly (Thiourea–Formaldehyde) Resin against Aquatic Microbes and Cytotoxic Activity

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Awadallah-F A.; Azzam A.M.; Mostafa B.B.; Kodous A.S.; Badr M.M.

Journal: Egyptian Journal of Aquatic Biology and Fisheries

Publisher: Egyptian Society for the Development of Fisheries and Human Health

Publication Date: 1 November 2022

Volume / Issue: Volume 26 / Issue 6

Pages: 511–524

ISSN: 11106131

DOI: 10.21608/ejabf.2022.273377

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Awadallah-F A., Radiation Research of Polymer Department, Industrial Irradiation Division, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Authority (EAEA), Cairo, Egypt; Azzam A.M., Environmental Research Department, Theodor Bilharz Research Institute (TBRI), Egypt; Mostafa B.B., Environmental Research Department, Theodor Bilharz Research Institute (TBRI), Egypt; Kodous A.S., Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt; Badr M.M., Polymer Laboratory, Petrochemical Division, Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo, Egypt

Abstract

Poly (thiourea–formaldehyde) resin (PTUFR) is synthesized by gamma rays. Fourier transform infrared (FTIR), 1H-NMR and 13C-NMR spectroscopy, transmission electron microscopy (TEM), and gel permeation chromatography (GPC) were the techniques used to characterize PTUFR. The results confirmed the formation of PTUFR. The antimicrobial activity of PTUFR was tested against the most resistant isolated aquatic microbes Gram-positive bacteria (Bacillus subtilis), Gram-negative bacteria (Pseudomonas aeruginosa), and fungi(Candida albicans). Through the interaction with internal cellular components and cell membranes, PTUFR showed potential for bio-application in inactivating microbial cells by killing them. The two cell death mechanisms of the reactions of PTUFR with the proteins of the cell wall led to reduced permeability, as well as reactive oxygen species (ROS) with high release rates from PTUFR, which in a row caused damage to DNA and cellular components. Furthermore, the cytotoxicity of PTUFR against human breast cancer MCF-7 and HepG2 liver cancer cells was studied. The cytotoxicity of PTUFR resulted in the inhibition of cell growth on the lines of the cancer cells. [Z1] The exposure of MCF-7 and HepG2 cancer cells to PTUFR for 48h displayed a potential apoptotic activity by significant upregulation of p53 gene expression and cytotoxic activity by downregulation of Bcl-2 gene expression. These results may also contribute to an unconventional strategy for environmental and medical applications, such as safe wastewater disinfection and cytotoxic activity. © 2022, Egyptian Society for the Development of Fisheries and Human Health. All rights reserved.

Keywords

Antimicrobial; Cytotoxic; Gamma rays; Poly (thiourea–formaldehyde) resin; Wastewater

Citation Information

Scopus Citations: 5

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