In vitro evaluation of antihelminthic activity of Praziquantel, Flubendazole and some plant extracts against the adult eye fluke (Philophthalamus palpebrarum) transmitted by the freshwater snail Melanoides tuberculata.

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Motleb A.; Ayoub M.; Tadros M.; Ramzy F.; El-Bardicy S.

Journal: Egyptian Journal of Aquatic Biology and Fisheries

Publisher: Egyptian Society for the Development of Fisheries and Human Health

Publication Date: 1 January 2022

Volume / Issue: Volume 26 / Issue 1

Pages: 491–503

Article No.: 31

ISSN: 11106131

DOI: 10.21608/EJABF.2022.220474

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Abdel-Motleb A., Environmental Research and Medical Malacology Division, Theodor Bilharz Research Institute, Egypt; Ayoub M., Environmental Research and Medical Malacology Division, Theodor Bilharz Research Institute, Egypt; Tadros M., Environmental Research and Medical Malacology Division, Theodor Bilharz Research Institute, Egypt; Ramzy F., Parasitology Division, Theodor Bilharz Research Institute, Egypt; El-Bardicy S., Parasitology Division, Theodor Bilharz Research Institute, Egypt

Abstract

Philophthalmus species (the eye flukes) are digenetic trematodes that cause damage to the ocular tissues of birds and humans. Diagnosis of subclinical philophthalmosis and effective therapeutic regimens are lacking, despite the increasing number of cases reported in birds and humans. So, the present study aimed to evaluate in vitro the antihelminthic activity of Praziquantel (PZQ), Flubendazole, and plant leaves extracts (Jatropha curcas and Moringa oleifera) against the adult eye fluke Philophthalamus palpebrarum (Philophthalmidae) which extracted from the conjunctival sac of the experimentally infected chickens eyes by excysted metacercariae The cercariae obtained from the naturally infected freshwater snails Melanoides tuberculata collected from watercourses in Giza Governorate, Egypt. The efficacy was determined based on the dead worms percentage after treatment and morphological changes recorded by scanning electron microscopy. The worms were incubated in the culture media with different concentrations tested materials up to 72 h. The calculated LC50were 7.857, 9.170, 65.534 &44.509μg/mL and LC90were 10.149, 13.489, 91.474 & 53.004μg/mL, respectively. Worms incubated for 48h with LC50 of PZQ and Moringa revealed deformity, swelling of oral and ventral suckers, erosion, and disorganization of the tegument when examined with scanning electron microscopy. It can be concluded that Praziquantel, Flubendazole, Jatropha curcas, and Moringa oleifera plant leaves extracts possess in vitro antiphilophthalamus activities; however, studies in vivo should be conducted to examine their antiphilophthalamus effects. © 2022, Egyptian Society for the Development of Fisheries and Human Health. All rights reserved.

Keywords

Flubendazole; Jatropha curcas; Moringa oleifera; Philophthalamus palpebrarum; Praziquantel

Citation Information

Scopus Citations: 0

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