Differential expression of metallothionein and p21 in gastric cancer and some precursor lesions

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Helal N.S.; Moussa M.M.; Aboushousha T.; Aboul-Ezz M.A.; Magdy M.

Journal: European Review for Medical and Pharmacological Sciences

Publisher: Verduci Editore s.r.l

Publication Date: 2022

Volume / Issue: Volume 26 / Issue 9

Pages: 3100–3108

ISSN: 11283602

DOI: 10.26355/eurrev_202205_28727

Scopus: View on Scopus

PubMed: 35587060

Document Type: Article

Authors and Affiliations

Helal N.S., Department of Pathology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Moussa M.M., Department of Pathology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Aboushousha T., Department of Pathology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Aboul-Ezz M.A., Department of Hepatology and Gastroenterology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Magdy M., Department of Pathology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt

Abstract

OBJECTIVE: Gastric cancer (GC) is a heterogeneous disease with molecular diversity between and within tumors; therefore, searching for altered genes within this cancer is mandatory to reach the proper individualized targeted therapy. Expressions of Metallothionein (MT) and p21 are not uniform in various types of cancers and their predictive value in GC is controversial. This study aimed to assess the role of MT and p21 in intestinal-type GC and some of its precursor lesions. MATERIALS AND METHODS: Immunohistochemical staining for MT and p21 was applied on paraffin blocks belonging to 30 GCs and 51 benign gastric lesions/precancerous lesions [33 chronic gastritis and 18 chronic gastritis with gastric intestinal metaplasia (GIM)]; 27 of them were associated with H. pylori infection. RESULTS: MT expression was dramatically increased while p21 expression was dramatically decreased from chronic gastritis to GIM to GC. In precancerous lesions, H. pylori-positive cases had significantly higher MT expression and lower p21 expression compared to H. pylori-negative cases. In GCs, decreased expression of both MT and p21 was associated with high-grade and advanced-stage cancers. CONCLUSIONS: Both MT and p21 may have a role in the development and progression of GC, and both proteins may be useful for selecting targeted therapy for GC patients. © 2022 Verduci Editore s.r.l. All rights reserved.

Keywords

Gastric cancer; H. pylori; Intestinal metaplasia; MT; p21; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Metallothionein; Metaplasia; Precancerous Conditions; Stomach Neoplasms; paraffin; protein p21; adult; Article; cancer grading; cancer staging; chronic gastritis; controlled study; disease association; female; Helicobacter infection; human; human cell; immunohistochemistry; major clinical study; male; middle aged; precancer; protein expression; stomach cancer; stomach carcinogenesis; stomach tissue; complication; genetics; metabolism; pathology; stomach mucosa; stomach tumor

Citation Information

Scopus Citations: 8

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